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105496-31-9

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105496-31-9 Structure

105496-31-9 Structure
IdentificationMore
[Name]

N-FMOC-ETHANOLAMINE
[CAS]

105496-31-9
[Synonyms]

2-(FMOC-AMINO)-ETHANOL
(2-HYDROXY-ETHYL)-CARBAMIC ACID 9H-FLUOREN-9-YLMETHYL ESTER
9-FLUORENYLMETHYL N-(2-HYDROXYETHYL)CARBAMATE
FMOC-2-AMINOETHANOL
FMOC-ETHANOLAMINE
FMOC-GLYCINOL
FMOC-GLY-OL
FMOC-NH-(CH2)2-OH
N-9-(FLUORENYLMETHOXYCARBONYL)-2-AMINOETHANOL
N-(9-FLUORENYLMETHOXYCARBONYL)ETHANOLAMINE
N-9-(FLUORENYLMETHOXYCARBONYL)-GLYCINOL
N-ALPHA-FMOC-GLYCINOL
N-FMOC-ETHANOLAMINE
N-Fmoc-ethanolamine,2-(Fmoc-amino)ethanol,9-FluorenylmethylN-(2-hydroxyethyl)carbamate
NALPHA-9-Fluorenylmethoxycarbonyl-2-aminoethanol
2-(9-Fluorenylmethyloxycarbonyl)amino-ethanol, N-alpha-(9-Fluorenylmethyloxycarbonyl)-glycinol
2-(Fmoc-amino)ethanol, 9-Fluorenylmethyl N-(2-hydroxyethyl)carbamate
9-Fluorenylmethyl N-(2-hydroxyethyl)carbamate, N-Fmoc-ethanolamine
[EINECS(EC#)]

626-390-8
[Molecular Formula]

C17H17NO3
[MDL Number]

MFCD00235927
[Molecular Weight]

283.32
[MOL File]

105496-31-9.mol
Chemical PropertiesBack Directory
[Melting point ]

144-147 °C (lit.)
[Boiling point ]

502.7±33.0 °C(Predicted)
[density ]

1.238±0.06 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMSO, Methanol
[form ]

Solid
[pka]

11.38±0.46(Predicted)
[color ]

White
[CAS DataBase Reference]

105496-31-9(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
[WGK Germany ]

3
[HS Code ]

29242990
Hazard InformationBack Directory
[Uses]

Fmoc-Glycinol is an Fmoc protected amino alcohol. Fmoc-Glycinol is used in the preparation of amphiphilic lactosides.
[reaction suitability]

reagent type: cross-linking reagent
[Synthesis]

N-(9-Fluorenylmethoxycarbonyloxy)succinimide

82911-69-1

Monoethanolamine

141-43-5

Fmoc-Glycinol

105496-31-9

GENERAL STEPS: A tetrahydrofuran (600 mL) solution of 2-aminoethanol (30 g, 491 mmol) was added to a 2000 mL round bottom flask, followed by 9-fluorenylmethyl-N-succinimidyl carbonate (166 g, 491 mmol) and triethylamine (199 g, 1.97 mol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (eluent: ethyl acetate/petroleum ether mixed solvent) to afford 2-(N-fluorenylmethoxycarbonylamino)ethanol (130 g, 93% yield) as a white solid.

[References]

[1] Journal of the American Chemical Society, 2014, vol. 136, # 47, p. 16683 - 16688
[2] Tetrahedron Letters, 2008, vol. 49, # 41, p. 5890 - 5893
[3] Patent: WO2015/51045, 2015, A2. Location in patent: Page/Page column 160
[4] Patent: US2016/215288, 2016, A1. Location in patent: Paragraph 0602; 0607
[5] Tetrahedron, 2007, vol. 63, # 28, p. 6577 - 6586
Spectrum DetailBack Directory
[Spectrum Detail]

Fmoc-Glycinol(105496-31-9)1HNMR
Fmoc-Glycinol(105496-31-9)FT-IR
Fmoc-Glycinol(105496-31-9)IR
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

105496-31-9(sigmaaldrich)
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