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LY 190388 is a penicillamine-containing enkephalin analog. It is an mu receptor agonist that produces analgesia.. | [Uses]
LY 190388 is a penicillamine-containing enkefa peptide analog with μ receptor agonist activity. LY 190388 showed analgesic effect in inhibiting the writhing response in mice after intracerebroventricular administration. The analgesic effect of LY 190388 is not caused by its δ receptor agonist action, but by its μ receptor agonist activity. When LY 190388 is used together with the δ receptor antagonist ICI 174864, an additive analgesic effect is produced[1]. | [References]
[1] Comparison of two penicillamine-containing enkephalins: mu, not delta, activity produces analgesia |
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Fuan Bio
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fuanbio.com |
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