| Identification | Back Directory | [Name]
CATHEPSIN L INHIBITOR I | [CAS]
105608-85-3 | [Synonyms]
Z-FF-FMK
CATHEPSIN L INHIBITOR I
Carbamic acid, N-[(1S)-2-[[(1S)-3-fluoro-2-oxo-1-(phenylmethyl)propyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester | [Molecular Formula]
C27H27FN2O4 | [MDL Number]
MFCD02264371 | [MOL File]
105608-85-3.mol | [Molecular Weight]
462.51 |
| Chemical Properties | Back Directory | [Boiling point ]
707.544±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.215±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
DMSO: Soluble: =10 mg/ml | [form ]
Solid | [pka]
11.070±0.46(predicted) | [color ]
White to off-white | [Sequence]
Z-Phe-Phe-FMK | [InChIKey]
CAILNONEKASNSH-ZEQRLZLVSA-N | [SMILES]
C(OCC1=CC=CC=C1)(=O)N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC1=CC=CC=C1)C(=O)CF)=O |
| Hazard Information | Back Directory | [Uses]
Z-FF-FMK is a selective cathepsin-L inhibitor. Z-FF-FMK can prevent β-amyloid to induce apoptotic changes such as activation of caspase-3, cleavage of the DNA repair enzyme, poly-ADP ribose polymerase, and DNA fragmentation[1]. | [References]
[1] cathepsin-L DOI:10.1016/s0197-4580(03)00034-4 |
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| Company Name: |
Nextpeptide Inc
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| Telephone: |
+86-0571-81612335 +8613336028439 |
| Website: |
http://www.nextpeptide.com/ |
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