| Identification | Back Directory | [Name]
2,2,6,6-TETRAMETHYL-4-PIPERIDONE MONOHYDRATE | [CAS]
10581-38-1 | [Synonyms]
TRIACETONEAMINE HYDRATE
2,2,6,6-TetraMethyl-4-piperidone Hydrate
2,2,6,6-TETRAMETHYL-4-PIPERIDONE MONOHYDRATE
2,2,6,6-Tetramethyl-4-Piperidone/Tripyruvalamine
4-Piperidinone, 2,2,6,6-tetramethyl-, monohydrate | [Molecular Formula]
C9H19NO2 | [MDL Number]
MFCD00149393 | [MOL File]
10581-38-1.mol | [Molecular Weight]
173.25 |
| Hazard Information | Back Directory | [Uses]
Triacetonamine (2,2,6,6-Tetramethyl-4-piperidone) monohydrate is used as an intermediate for the synthesis of pharmaceutical products, pesticides and photostabilizers for polymers. Triacetonamine hydrochloride has oral activity and can induce acute liver failure (ALF) in rats[1][2]. | [in vivo]
Triacetonamine (Purchased from MCE; 200 mg, 300 mg, 400 mg/Kg/day; gavage; 2 days) monohydrate shows typical hepatoenteropathology of ALF with 300 mg/Kg/day and 400 mg/Kg/day, while the group of 400 mg/Kg/day had higher mortality[2]. | Animal Model: | Rats (half male and female, 6-8 weeks old, 200±10 g)[2] | | Dosage: | 200 mg, 300 mg, 400 mg/Kg | | Administration: | Gavage; daily; 2 days | | Result: | Showed typical hepatoenteropathology of ALF with 300 mg/Kg/day and 400 mg/Kg/day, while the group of 400 mg/Kg/day had higher mortality.
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| [References]
[1] Cao JP, et al. Triacetonamine formation in a bio-oil from fast pyrolysis of sewage sludge using acetone as the absorption solvent. Bioresour Technol. 2010;101(11):4242-4245. DOI:10.1016/j.biortech.2010.01.031
[2] Cao JP, et al. Triacetonamine formation in a bio-oil from fast pyrolysis of sewage sludge using acetone as the absorption solvent. Bioresour Technol. 2010 Jun;101(11):4242-5. DOI:10.1016/j.biortech.2010.01.031
[3] Ting Jiang, et al. Application of Bone Marrow Mesenchymal Stem Cells Effectively Eliminates Endotoxemia to Protect Rat from Acute Liver Failure Induced by Thioacetamide. Tissue Eng Regen Med. 2022 Apr;19(2):403-415. DOI:10.1007/s13770-021-00421-5 |
| Spectrum Detail | Back Directory | [Spectrum Detail]
2,2,6,6-TETRAMETHYL-4-PIPERIDONE MONOHYDRATE(10581-38-1)MS
2,2,6,6-TETRAMETHYL-4-PIPERIDONE MONOHYDRATE(10581-38-1)1HNMR
2,2,6,6-TETRAMETHYL-4-PIPERIDONE MONOHYDRATE(10581-38-1)13CNMR
2,2,6,6-TETRAMETHYL-4-PIPERIDONE MONOHYDRATE(10581-38-1)IR1
2,2,6,6-TETRAMETHYL-4-PIPERIDONE MONOHYDRATE(10581-38-1)IR2
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| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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