| Identification | Back Directory | [Name]
5-KETE | [CAS]
106154-18-1 | [Synonyms]
5-KETE
5-OXOETE
5-OxoETE MaxSpec Standard
MEASLHGILYBXFO-XTDASVJISA-N
5-OxoETE Lipid Maps MS Standard
5-OXO-6E,8Z,11Z,14Z-EICOSATETRAENOIC ACID
5-KETOEICOSA-6E,8Z,11,Z14Z-TETRAENOIC ACID
5-Oxo-(6E,8Z,11Z,14Z)-6,8,11,14-eicosatetraenoicacid
6,8,11,14-Eicosatetraenoic acid, 5-oxo-, (6E,8Z,11Z,14Z)- | [Molecular Formula]
C20H30O3 | [MDL Number]
MFCD00216129 | [MOL File]
106154-18-1.mol | [Molecular Weight]
318.45 |
| Chemical Properties | Back Directory | [Boiling point ]
495.0±45.0 °C(Predicted) | [density ]
0.980±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -80°C | [solubility ]
DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml | [form ]
Liquid. | [pka]
4.59±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils by a specific dehydrogenase.1 It stimulates cytosolic calcium levels in neutrophils with an EC50 value of 2 nM.2 5-OxoETE selectively stimulates the migration and degranulation of eosinophils and activates the MAPK pathway in stimulated neutrophils via a specific G protein-coupled receptor.3,4,5,6
5-OxoETE MaxSpec® standard is a quantitative grade standard of 5-oxoETE (Item No. 34250) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 5-oxoETE MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality. | [Uses]
5-oxo-ETE is a compound that stimulates neutrophil degranulation. | [Definition]
ChEBI: 5-oxo-ETE is an oxoicosatetraenoic acid having a 5-oxo group; and (6E)-, (8Z), (11Z)- and (14Z)-double bonds. It has a role as a human metabolite, a mouse metabolite and an immunomodulator. It is functionally related to an icosa-6,8,11,14-tetraenoic acid. It is a conjugate acid of a 5-oxo-ETE(1-). | [Biological Activity]
Potent oxoeicosanoid (OXE) receptor agonist (EC 50 = 0.33 nM). Chemoattractant for both neutrophils and eosinophils and induces transendothelial migration of eosinophils. | [storage]
Store at -80°C,protect from light |
|
| Company Name: |
|
| Tel: |
821-50328103-801 18930552037 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList13285/0.htm |
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
amyjetsci
|
| Tel: |
027-59626688 18771149750 |
| Website: |
https://www.amyjet.com/ |
| Company Name: |
|
| Tel: |
4008-099-669 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList112975/0.htm |
| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|