| Identification | Back Directory | [Name]
Hederacolchiside A1 | [CAS]
106577-39-3 | [Synonyms]
Raddeanoside R13
Hederacolchiside A1
HEDERACOLCHISIDE A1;
Hederacolchiside A1 USP/EP/BP
Oleanolic acid-3-O-β-D-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)-]-α-L-arabinopyranoside，Hederacolchiside A1
Olean-12-en-28-oicacid, 3-[(O-6-deoxy-a-L-mannopyranosyl-(12)-O-[b-D-glucopyranosyl-(14)]-a-L-arabinopyranosyl)oxy]-, (3b)-
Olean-12-en-28-oic acid, 3-[(O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosyl)oxy]-, (3β)- | [Molecular Formula]
C47H76O16 | [MOL File]
106577-39-3.mol | [Molecular Weight]
897.1 |
| Chemical Properties | Back Directory | [Melting point ]
253-255℃ (methanol , water ) | [Boiling point ]
967.2±65.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
4°C, protect from light | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
4?+-.0.70(Predicted) | [color ]
White to off-white | [Cosmetics Ingredients Functions]
SKIN CONDITIONING |
| Hazard Information | Back Directory | [Uses]
Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway[1]. Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro[2]. | [in vivo]
hederacolchiside A1 (3.0, 4.5, and 6.0?mg/kg, ip) can significantly inhibit the weight of tumor in an H22 xenograft model[1].
Hederacolchiside A1 (3.25, 7.5, and 15.0?mg/kg, ig) can significantly inhibit the weight of tumor in nude mice xenograft tumor models using human breast carcinoma MCF-7 cells[1].
| [IC 50]
Schistosome; PI3K; mTOR | [References]
[1] Yan-Er Wang, et al. Hederacolchiside A1 suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway. Chinese Herbal Medicines.Volume 10, Issue 2, April 2018, Pages 215-222
[2] Kang N, et al. Antischistosomal Properties of Hederacolchiside A1 Isolated from Pulsatilla chinensis. Molecules. 2018 Jun 13;23(6). DOI:10.3390/molecules23061431 |
|
|