| Identification | Back Directory | [Name]
PULCHINENOSIDE B4 | [CAS]
129741-57-7 | [Synonyms]
Anemoside B4
Chinensioside A
Pulchinenoside C
PULCHINENOSIDE B4
Pulsatilla saponin B4
AnemosideB4 129741-57-7
Anemoside B4 Pulchinenoside B4
Pulchinenoside C (Anemoside B4)
Pulchinenoside B4, 98%, from Pulsatilla chinensis (Bunge) Regel
Lup-20(29)-en-28-oic acid, 3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxy-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, (3β,4α)- | [Molecular Formula]
C59H96O26 | [MDL Number]
MFCD11215450 | [MOL File]
129741-57-7.mol | [Molecular Weight]
1221.38 |
| Chemical Properties | Back Directory | [Melting point ]
208-215℃ | [density ]
1.48 | [solubility ]
DMSO : 125 mg/mL (102.34 mM; Need ultrasonic) | [form ]
Powder | [pka]
12.50±0.70(Predicted) | [color ]
White to light yellow | [InChIKey]
OUHBKBTZUPLIIA-UFEMLMIJNA-N |
| Hazard Information | Back Directory | [Description]
Pulchinenoside B4 is a triterpenoid glycoside that has been found in P. chinensis and has diverse biological activities.1,2 It inhibits cisplatin-induced apoptosis, increases in reactive oxygen species (ROS) production, and decreases in superoxide dismutase (SOD) and catalase activities in HEK293 cells when used at concentrations of 6 and 12 μM.1 Pulchinenoside B4 (50 and 100 mg/kg twice per day) prevents increases in plasma blood urea nitrogen (BUN) and creatinine levels, markers of kidney injury, in a mouse model of cisplatin-induced nephrotoxicity. It prevents xylene-induced ear edema in mice in a dose-dependent manner.2 Pulchinenoside B4 (50 mg/kg) inhibits LPS-induced increases in serum TNF-α, IL-6, and IL-1β levels a mouse model of LPS-induced systemic inflammation. | [Chemical Properties]
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the dried roots of Pulsatilla chinensis (Bge.) Regel. | [Uses]
Pulchinenoside C is a triterpenoid saponin extract which acts as a minor molluscicidal agent in addition to tumor necrosis factor-α secretion inhibition. Anti-inflammatory. | [References]
[1] HE LUAN . Anemoside B4 attenuates nephrotoxicity of cisplatin without reducing anti-tumor activity of cisplatin[J]. Phytomedicine, 2019, 56: Pages 136-146. DOI: 10.1016/j.phymed.2018.10.035
[2] NAIXIN KANG . Anti-inflammatory and immune-modulatory properties of anemoside B4 isolated from Pulsatilla chinensis in vivo[J]. Phytomedicine, 2019, 64: Article 152934. DOI: 10.1016/j.phymed.2019.152934 |
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