ChemicalBook--->CAS DataBase List--->1066-17-7

1066-17-7

1066-17-7 Structure

1066-17-7 Structure
IdentificationBack Directory
[Name]

COLISTIN
[CAS]

1066-17-7
[Synonyms]

COLISTIN
kangdisu
totazina
colimycin
colomycin
coly-mycin
colymysins
kolimitsin
Aids033059
Aids-033059
colisticina
Polyoxin W.P.
1264-72-8 (Sulfate)
PolyMyxin E coMplex
Polymyxin E1 sulfate
Colistin, ColiMycin M, BelcoMycin, ColyMycin, Torazin
[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(1S,4S,7R,10S,13S,16S,19S)-4,13,16-tris(2-aminoethyl)-19-[(1R)-1-hydroxyethyl]-10-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-7-(phenylmethyl)-3,6
[EINECS(EC#)]

213-907-3
[Molecular Formula]

C52H98N16O13
[MDL Number]

MFCD05662338
[MOL File]

1066-17-7.mol
[Molecular Weight]

1155.43
Chemical PropertiesBack Directory
[Boiling point ]

807.67°C (rough estimate)
[density ]

1.1050 (rough estimate)
[refractive index ]

1.6700 (estimate)
[storage temp. ]

Store at -20°C
[solubility ]

PBS (pH 7.2): 10 mg/ml
[CAS DataBase Reference]

1066-17-7
Hazard InformationBack Directory
[Uses]

Polymyxin E (colistin) is a complex of closely related cyclic peptides E1 and E2, with additional minor analogues. Polymyxin E is produced by Bacillus polymyxa var. colistinus, and is a highly basic, atypical cyclic peptide which incorporates the unusual amino acid, diaminobutyric acid. Head-to-tail coupling of lysine completes the macrocycle. Balancing the polar cyclic peptide is a hydrophobic tail with short chain fatty acids. Polymyxin E is a broad spectrum antibiotic active against Gram negative bacteria. The mechanism of action involves disruption of the bacterial outer membrane by a detergent-like effect.
[Brand name]

Coly-Mycin (Monarch).
[storage]

Store at -20°C
Safety DataBack Directory
[RIDADR ]

3249
[HazardClass ]

6.1(b)
[PackingGroup ]

III
[Hazardous Substances Data]

1066-17-7(Hazardous Substances Data)
[Toxicity]

cat,LDLo,subcutaneous,250mg/kg (250mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGBEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Antibiotiki. Vol. 5(4), Pg. 10, 1960.
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Colistin sulfate
Questions And AnswerBack Directory
[Neurotoxicity and Nephrotoxicity]

Colistin is an antibiotic which is being used more commonly now than when it was introduced because of its activity against multiresistant Gram-negative bacteria, especially Acinetobacter baumanii and Enterobacteriaceae producing extended spectrum β-lactamases. It had a bad reputation due to reports of neurotoxicity and nephrotoxicity. Recent studies have shown lower rates of nephrotoxicity than previously reported. However, in one of these reports, 7/42 patients with high serum creatinine values prior to colistin treatment developed renal failure.
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