Back to ChemicalBook Home--->CAS DataBase List--->2999-46-4

2999-46-4

2999-46-4 Structure

2999-46-4 Structure
IdentificationMore
[Name]

Ethyl isocyanoacetate
[CAS]

2999-46-4
[Synonyms]

BIO-FARMA BF001872
ETHYL ISOCYANOACETATE
HANSA ISN-0528
ISOCYANOACETIC ACID ETHYL ESTER
Ethylisocyanoacetate,98%
Acetic acid, isocyano-, ethyl ester
(2-Oxo-2-ethoxyethyl) isocyanide
2-Oxo-2-ethoxyethyl isocyanide
Ethoxycarbonylmethyl isocyanide
Ethyl 2-isocyanoacetate
[EINECS(EC#)]

221-077-9
[Molecular Formula]

C5H7NO2
[MDL Number]

MFCD00000007
[Molecular Weight]

113.11
[MOL File]

2999-46-4.mol
Chemical PropertiesBack Directory
[Appearance]

Light yellow to brom liquid
[Boiling point ]

194-196 °C (lit.)
[bp ]

194-196 °C(lit.)
[density ]

1.035 g/mL at 25 °C(lit.)
[refractive index ]

n20/D 1.418(lit.)
[Fp ]

184 °F
[storage temp. ]

2-8°C
[form ]

Liquid
[color ]

Clear amber to dark brown
[Water Solubility ]

Miscible with organic solvents. Slightly miscible with water.
[Sensitive ]

Moisture & Light Sensitive
[BRN ]

3588613
[CAS DataBase Reference]

2999-46-4(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

R20/22:Harmful by inhalation and if swallowed .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
[Safety Statements ]

S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves .
[RIDADR ]

UN 2810 6.1/PG 3
[WGK Germany ]

3
[F ]

8-9-21
[HazardClass ]

6.1
[PackingGroup ]

III
[HS Code ]

29299090
Raw materials And Preparation ProductsBack Directory
【Preparation Products】

5-PHENYL-1,3-OXAZOLE-4-CARBONYL CHLORIDE-->ETHYL3-METHYL-2-INDOLECARBOXYLATE-->Diethyl 1H-pyrrole-2,4-dicarboxylate-->ETHYL ISOTHIOCYANATOACETATE-->ethyl 4-formyl-1H-pyrrole-2-carboxylate
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Ethyl isocyanoacetate(2999-46-4).msds
Hazard InformationBack Directory
[Chemical Properties]

Light yellow to brom liquid
[Uses]

Ethyl Isocyanoacetate, is a cyclization synthon used to prepare pyrroles, oxazolines, benzodiazepines, oxazoles and imidazoles. Ethyl isocyanoacetate can be used to prepare pyrroles,1,2 oxazolines, benzodiazepines, oxazoles and imidazoles.
[Preparation]

synthesis of ethyl isocyanoacetate
A solution containing N-formyl glycine ethyl ester (1, 1.31 g, 10 mmol), DIPEA (2.62 g, 20 mmol) and DMAP (0.45 g, 3 mmol) in dry DCM (10 mL) was loaded in a sample loop and combined with a second stream containing triphosgene (2, 0.98 g, 3.3 mmol) also dissolved in dry DCM (10 mL) at individual channel flow rates of 0.5 mL/min. The combined stream was directed into two linked 10 mL FEP reactor vessels to achieve a 20 minutes residence time at ambient temperature. The output was collect and the solvent was carefully evaporated to 80% of its total volume. The crude material was filtered through silica (5 g) and washed with DCM (2 × 10 mL) to obtain the salt-free product. The desired product 3 was obtained as dark yellow oil after evaporation of the organic phase (1.03 g, 91 % isolated yield, >97% purity by 1H NMR).
Spectrum DetailBack Directory
[Spectrum Detail]

Ethyl isocyanoacetate(2999-46-4)MS
Ethyl isocyanoacetate(2999-46-4)1HNMR
Ethyl isocyanoacetate(2999-46-4)13CNMR
Ethyl isocyanoacetate(2999-46-4)IR1
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

Ethyl isocyanoacetate, 97%(2999-46-4)
[Alfa Aesar]

Ethyl isocyanoacetate, 98%(2999-46-4)
[Sigma Aldrich]

2999-46-4(sigmaaldrich)
[TCI AMERICA]

Ethyl Isocyanoacetate,>95.0%(GC)(2999-46-4)
2999-46-4 suppliers list
Company Name: Frapp's ChemicalNFTZ Co., Ltd.
Tel: +86 (576) 8169-6106
Fax: +86 (576) 8169-6105
Website: www.frappschem.com
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-66670886
Fax:
Website: https://www.dakenchem.com/
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd
Tel: 010-60279497
Fax: 010-60279497
Website: http://www.cooperate-pharm.com
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Fax: 0371-55170693
Website: http://www.tianfuchem.net/
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +86 21 5161 9050/ 5187 7795
Fax: +86 21 5161 9052/ 5187 7796
Website: www.atkchemical.com
Company Name: Zhejiang ZETian Fine Chemicals Co. LTD
Tel: 18957127338
Fax:
Website: http://www.zetchem.com/
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-18871470254
Fax: 027-59599243
Website: www.hubeijusheng.com
Company Name: Chongqing Chemdad Co.,Ltd
Tel: +86-19923101450
Fax:
Website: www.chemdad.com
Company Name: Xiamen AmoyChem Co., Ltd
Tel: +86 592-605 1114
Fax:
Website: www.amoychem.com
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Fax: 027-59338440
Website: www.chemicalbook.com/ShowSupplierProductsList1549548/0.htm
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-13650506873
Fax:
Website: http://www.chemdad.com/
Company Name: Hebei Xibaijie Biotechnology Co., Ltd.
Tel: 0086 15232103582
Fax:
Website: www.hbxibaijie.com
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: 86-18523575427
Fax:
Website: http://www.conier.com/
Company Name: career henan chemical co
Tel: 0371-55982848 , 15093356674
Fax: 0086-371-86658258
Website: www.coreychem.com
Company Name: Zhuozhou Wenxi import and Export Co., Ltd
Tel: +8613111626072 (WhatsApp)
Fax: Wechat: +8613111626072 Wickr me: waynehu
Website: www.wenxichem-pharma.com
Company Name: Richest Group Ltd
Tel: 18017061086
Fax:
Website: www.richest-oled.com
Company Name: Antai Fine Chemical Technology Co.,Limited
Tel: 18503026267
Fax:
Website:
Company Name: Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
Tel: 13580539051
Fax:
Website: www.yuhengpharm.com
Tags:2999-46-4 Related Product Information
1873-29-6 24801-88-5 190774-50-6 110-78-1 621-29-4 39687-95-1 404-71-7 63009-74-5 40398-01-4 33522-03-1 2253-73-8 52395-66-1 5395-71-1 2290-65-5 556-61-6 1195-45-5 16182-04-0 3173-56-6