106635-81-8

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106635-81-8 Structure

Identification	Back Directory
[Name] TAFENOQUINE SUCCINATE
[CAS] 106635-81-8
[Synonyms] WR-238605 SB-252263 Krintafel SB 252263AX Wr238605 succinate Tafenoquine Succinate N-[2,6-Dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl]pentane-1,4-diamine 8-[(4-Amino-1-methylbutyl)amino]-2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinoline succinate TAFENOQUINE SUCCINATE; WR-238605, WR 238605, WR238605, SB-252263-AAB; SB252263-AAB; SB 252263-AAB; KRINTAFEL; Butanedioic acid, compd. with N(sup 4)-(2,6-dimethoxy-4-methyl-5-(3-(trifluoromethyl)phenoxy)-8-quinolinyl)-1,4-pentanediamine (1:1)
[Molecular Formula] C28H34F3N3O7
[MDL Number] MFCD00892249
[MOL File] 106635-81-8.mol
[Molecular Weight] 581.581

Chemical Properties	Back Directory
[Melting point ] 146-149°
[storage temp. ] 2-8°C
[solubility ] DMSO: soluble5mg/mL (clear solution)
[form ] powder
[color ] white to beige

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H302-H315-H319-H335
[Precautionary statements ] P261-P280-P301+P312-P302+P352-P305+P351+P338
[WGK Germany ] 3
[Toxicity] LD50 in male, female rats (mg/kg): 102, 71 i.p.; 429, 416 orally (LaMontagne)

Hazard Information	Back Directory
[Uses] Tafenoquine succinate is a new 8-aminoquinoline with an improved therapeutic index and safety profile as compared to primaquine (P733500).Tafenoquine has the potential to become a widely used drug in the preven tion and treatment of malaria infection and could replace some currently used drugs as resistant strains of Plasmodium species increase.
[Biochem/physiol Actions] Tafenoquine is an antimalarial primaquine analog being investigated to treat and prevent Plasmodium vivax infections. It can eliminate both blood and liver stages of Plasmodium vivax. Tafenoquine has also been tested as a therapy for leishmaniasis.

Spectrum Detail	Back Directory
[Spectrum Detail] TAFENOQUINE SUCCINATE(106635-81-8)¹HNMR

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