| Identification | Back Directory | [Name]
N2,N4-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine | [CAS]
1071098-42-4 | [Synonyms]
N2,N4-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine
N2,N?-bis(2-Methyl-1H-indol-5-yl)pyrimidine-2,4-diamine | [Molecular Formula]
C22H20N6 | [MOL File]
1071098-42-4.mol | [Molecular Weight]
368.43 |
| Chemical Properties | Back Directory | [Boiling point ]
711.0±70.0 °C(Predicted) | [density ]
1.388±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 100mg/mL | [form ]
Solid | [pka]
17.48±0.30(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Description]
AZA1 is a Rac1/Cdc42 GTPase-specific inhibitor which suppresses prostate cancer. | [Uses]
AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion[1][2]. | [in vivo]
AZA1 (Rac1/Cdc42-IN-1) (100 μg; i.p.; daily for 2 weeks) is potent in suppressing human 22Rv1 xenograft growth in mice and improving survival[1]. | Animal Model: | 5 week-old athymic nu/nu (nude) mice (bearing 22Rv1 prostate cancer cell xenografts)[1] | | Dosage: | 100 μg in 100 μl 30% DMSO | | Administration: | I.p.; daily for 2 weeks | | Result: | The suppressive effect of AZA1 on tumor growth was significant.
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| [References]
[1] Zins K, et al. A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice. PLoS One. 2013;8(9):e74924. Published 2013 Sep 11. DOI:10.1371/journal.pone.0074924
[2] Suzuki O, et al. Sialylation and glycosylation modulate cell adhesion and invasion to extracellular matrix in human malignant lymphoma: Dependency on integrin and the Rho GTPase family. Int J Oncol. 2015;47(6):2091‐2099. DOI:10.3892/ijo.2015.3211 |
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| Company Name: |
Struchem Co., Ltd.
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| Tel: |
0512-0512-63009836 15365350169 |
| Website: |
http://www.struchem.com |
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