| Identification | More | [Name]
2-Methoxy-4,6-dichloropyrimidine | [CAS]
1074-40-4 | [Synonyms]
2-methoxy-4,6-dichloropyrimidine
4,6-DICHLORO-2-METHOXY-PYRIMIDINE | [Molecular Formula]
C5H4Cl2N2O | [MDL Number]
MFCD03428360 | [Molecular Weight]
179 | [MOL File]
1074-40-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Pale Yellow Solid | [Melting point ]
59-60°C | [Boiling point ]
105°C (11 Torr) | [density ]
1.446 | [Fp ]
119°C | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
Chloroform, Methanol | [form ]
Solid | [pka]
-4.52±0.30(Predicted) | [color ]
Pale Yellow | [InChI]
InChI=1S/C5H4Cl2N2O/c1-10-5-8-3(6)2-4(7)9-5/h2H,1H3 | [InChIKey]
WDELVDLDINRUQF-UHFFFAOYSA-N | [SMILES]
C1(OC)=NC(Cl)=CC(Cl)=N1 | [CAS DataBase Reference]
1074-40-4(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Solid | [Synthesis]
Step 2: Synthesis of 4,6-dichloro-2-methoxypyrimidine; 2.25 g (7.92 mmol) of 4,6-dihydroxy-2-methoxypyrimidine and 10.0 mL (108.92 mmol) of phosphorus trichloride were mixed and the reaction was heated to reflux for 2 hours. Upon completion of the reaction, the reaction mixture was slowly poured into pre-cooled alkaline ice water and the pH was adjusted to alkaline with sodium hydroxide solution. Subsequently, the aqueous phase was extracted with dichloromethane. The organic phase was separated, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. A product of 0.20 g was obtained in 14% yield. The product was analyzed by ESI-MS showing m/z = 179 ([M + H]+) and an HPLC retention time (Method B) of 1.38 min. | [Toxics Screening Level]
Due to a lack of available toxicity information the ITSL is being set at the default value of
0.1 μg/m3 with annual averaging, based on R232(1)(i). | [References]
[1] Patent: WO2007/65940, 2007, A1. Location in patent: Page/Page column 49-50
[2] Patent: US2012/88755, 2012, A1. Location in patent: Page/Page column 67 |
|
| Company Name: |
Cool Pharm, Ltd Gold
|
| Telephone: |
021-58581007 18019463053 |
| Website: |
http://www.coolpharm.com.cn |
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
|