| Identification | Back Directory | [Name]
11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA | [CAS]
107615-77-0 | [Synonyms]
VKTIONYPMSCHQI-KGILNJEGSA-N
11β-13,14-dihydro-15-keto Prostaglandin F2α
11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA
9ALPHA, 11BETA-DIHYDROXY-15-OXO-PROST-5Z-EN-1-OIC ACID | [Molecular Formula]
C20H34O5 | [MDL Number]
MFCD00216071 | [MOL File]
107615-77-0.mol | [Molecular Weight]
354.48 |
| Chemical Properties | Back Directory | [solubility ]
10 mM Na2CO3: >6.5 mg/ml (from PGF2a); DMF: >100 mg/ml (from PGF2a); DMSO: >100 mg/ml (from PGF2a); Ethanol: >100 mg/ml (from PGF2a); PBS pH 7.2: >10 mg/ml (from PGF2a) |
| Hazard Information | Back Directory | [Description]
11β-13,14-dihydro-15-keto PGF2α is a metabolite of PGD2 in the 15-hydroxy PGDH pathway.1,2 Infusion or inhalation of tritiated PGD2 in normal males results in the appearance of peak levels of both 11β-PGF2α, as the immediate product, and 11β-13,14-dihydro-15-keto PGF2α in the plasma within 10 minutes.1 Homogenates of human lung metabolize PGD2 first to 11β-PGF2α and then to 11β-15-keto-PGF2α in the presence of NAD+, but not 11β-13,14-dihydro-15-keto PGF2α.2 Guinea pig liver and kidney homogenates metabolize PGD2 to 11β-13,14-dihydro-15-keto PGF2α, via 11β-PGF2α, in the presence of NAD+ and NADP+.2 | [Definition]
ChEBI: 11beta-13,14-dihydro-15-keto-PGF2alpha is a prostanoid. | [References]
1. Robinson, C., Hardy, C.C., and Holgate, S.T. The metabolism of prostaglandin D2 after inhalation or intravenous infusion in normal men Biochim. Biophys. Acta 963(2),151-161(1988).
2. Robinson, C., Herbert, C.A., Bedwell, S., et al. The metabolism of prostaglandin D2. Evidence for the sequential conversion by NADPH and NAD+ dependent pathways Biochem. Pharmacol. 38(19),3267-3271(1989). |
|
| Company Name: |
Boao Pike
|
| Tel: |
010-57798038 15652371397 |
| Website: |
www.biopike.cn |
|