| Identification | Back Directory | [Name]
β-nicotinamide mononucleotide, reduced form, disodium salt(NMNH) | [CAS]
108347-85-9 | [Synonyms]
NMNH β-nicotinamide mononucleotide, reduced form, disodium salt
β-nicotinamide mononucleotide, reduced form, disodium salt(NMNH) | [Molecular Formula]
C11H18N2NaO8P | [MOL File]
108347-85-9.mol | [Molecular Weight]
360.23 |
| Questions And Answer | Back Directory | [Preparation]
179 mg of MnCl2 was added to 2.85 L of Tris-HCl (50 mM) solution to adjust the pH to 8.0, and the temperature was maintained at 37 °C. 143 mg of NAD+ pyrophosphatase from *E. coli* (EcNADD) and 10 g of NADH were added to the solution, and the mixture was stirred for 2 hours. The NMNH solution was obtained by preparative chromatography, the pH was adjusted to 10 with NaOH, and the solution was concentrated under reduced pressure to obtain 3.8 g of β-nicotinamide mononucleotide, reduced form, disodium salt(NMNH) solid. |
| Chemical Properties | Back Directory | [form ]
Solid | [color ]
Light yellow to yellow | [InChIKey]
LSKSZICSFLRXJW-RAJFINMANA-N | [SMILES]
O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=CCC(C(=O)N)=C1)O.[NaH] |&1:1,2,3,11,r| |
| Hazard Information | Back Directory | [Description]
NMNH (reduced Nicotinamide Mononucleotide) is a new potent NAD+ precursor. It is a new form of NMN, can increase NAD levels to a much higher extent.
NMNH is a fluorescent molecule, in contrast to NMN. The molecular formulae for NMNH is C11H17N2O8P and it is also known as 1-(5-O-phosphono-beta-D-ribofuranosyl) -1,4-dihydropyridine-3-carboxamide Reduced nicotinamide mononucleotide. | [Uses]
β-Nicotinamide mononucleotide, reduced form disodium (β-NMN) is the oxidized form of NAD+ precursor and is a NAD+ enhancer. β-Nicotinamide mononucleotide, reduced form disodium can be reduced to dihydronicotinamide mononucleotide (NMNH). NMNH inhibits glycolysis, TCA cycle, and cell growth[1]. | [General Description]
β-Nicotinamide mononucleotide, reduced form disodium (β-NMN) is the
oxidized form of NAD+ precursor and is a NAD+ enhancer. β-Nicotinamide
mononucleotide, reduced form disodium can be reduced to
dihydronicotinamide mononucleotide (NMNH). NMNH inhibits glycolysis, TCA
cycle, and cell growth. | [storage]
2-8°C | [References]
[1] Liu Y, et al. Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+ and Suppresses Glycolysis, the TCA Cycle, and Cell Growth. J Proteome Res. 2021 May 7;20(5):2596-2606. DOI:10.1021/acs.jproteome.0c01037 |
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OXSYNS Gold
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Jiangsu Enzymatic Co.,Ltd. Gold
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