| Chemical Properties | Back Directory | [Melting point ]
129-132 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7)) | [Boiling point ]
383.6±30.0 °C(Predicted) | [density ]
1.182±0.06 g/cm3(Predicted) | [pka]
7.04±0.40(Predicted) |
| Hazard Information | Back Directory | [Description]
PD 120697 is a dopamine antagonist. It is a novel class of compounds with central dopamine agonist properties. It has been identified as orally active dopamine (DA) agonists with pronounced central nervous system effects in tests that include [3H]-haloperidol and [3H]-N-propylnorapomorphine binding, inhibition of striatal DA synthesis, inhibition of DA neuronal firing, inhibition of spontaneous locomotor activity, and reversal of reserpine-induced depression in rats. | [Uses]
PD 120697 is an orally active dopamine (DA) agonist. PD 120697 inhibits striatal DA synthesis, DA neuronal firing, spontaneous locomotor activity, and reverses Reserpine (HY-N0480)-induced depression[1]. | [References]
[1] Jaen JC, et al. 4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines: a novel class of compounds with central dopamine agonist properties. J Med Chem. 1990 Jan;33(1):311-7. DOI:10.1021/jm00163a051 |
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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