| Identification | Back Directory | [Name]
AC-93253 IODIDE | [CAS]
108527-83-9 | [Synonyms]
AC-93253
AC-93253 IODIDE
2-[3-(1,3-Dihydro-1,3,3-trimethyl-2H-indol-2-ylidene)-1-propenyl]-3-ethyl-benzothiazolium iodide | [Molecular Formula]
C23H25N2SI | [MDL Number]
MFCD03769029 | [MOL File]
108527-83-9.mol |
| Hazard Information | Back Directory | [Uses]
AC-93253 Iodide is a RAR agonist. It is also a SIRT2 and Src inhibitor. It triggers the downregulation of melanoma progression markers and the inhibition of melanoma cell proliferation. | [Biological Activity]
AC-93253 is a potentcell permeablesubtype selective RAR (RARα) agonist. EC50 = 6.3 μM. AC-93253 has high selectivity; 89% for RARα vs 67% for RARβ135% for RARβ2and 11% for RARγ. | [IC 50]
SIRT1: 45.3 μM (IC50); SIRT2: 6 μM (IC50); SIRT3: 24.6 μM (IC50) |
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| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
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21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
SIGMA-RBI
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800 736 3690 (Orders) |
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www.sigma-aldrich.com |
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