| Identification | Back Directory | [Name]
AC-93253 IODIDE | [CAS]
108527-83-9 | [Synonyms]
AC-93253
AC-93253 IODIDE
2-[3-(1,3-Dihydro-1,3,3-trimethyl-2H-indol-2-ylidene)-1-propenyl]-3-ethyl-benzothiazolium iodide | [Molecular Formula]
C23H25N2SI | [MDL Number]
MFCD03769029 | [MOL File]
108527-83-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
185-188 °C | [storage temp. ]
2-8°C | [solubility ]
DMSO: >10mg/mL | [form ]
solid | [color ]
dark purple | [InChI]
1S/C23H25N2S.HI/c1-5-25-19-13-8-9-14-20(19)26-22(25)16-10-15-21-23(2,3)17-11-6-7-12-18(17)24(21)4;/h6-16H,5H2,1-4H3;1H/q+1;/p-1 | [InChIKey]
TWBRXRGFFUATNI-UHFFFAOYSA-M | [SMILES]
[I-].CC[n+]1c(\C=C\C=C2\N(C)c3ccccc3C2(C)C)sc4ccccc14 |
| Hazard Information | Back Directory | [Uses]
AC-93253 Iodide is a RAR agonist. It is also a SIRT2 and Src inhibitor. It triggers the downregulation of melanoma progression markers and the inhibition of melanoma cell proliferation. | [Biological Activity]
AC-93253 is a potentcell permeablesubtype selective RAR (RARα) agonist. EC50 = 6.3 μM. AC-93253 has high selectivity; 89% for RARα vs 67% for RARβ135% for RARβ2and 11% for RARγ. | [IC 50]
SIRT1: 45.3 μM (IC50); SIRT2: 6 μM (IC50); SIRT3: 24.6 μM (IC50) |
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| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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