| Identification | Back Directory | [Name]
(2-CYANOETHOXY)-2-(2''-O-1,1''-DIMETHOXYTRITYLOXYETHYLSULFONYL)- ETHOXY-N,N-DIISOPROPYLAMINOPHOSPHINE) | [CAS]
108783-02-4 | [Synonyms]
Phostel
5' PHOSPHORYLATING I AMIDITE
Chemical Phosphorylation Reagent
Chemical Phosphorylation Reagent I
2-O-DMT-sulfonyldiethanol phosphoramidite
2-[2-(4,4'-Dimethoxytrityloxy)ethylsulfonyl]ethyl-(2-cyanoethyl)-(N,N-diisopropyl)-Phosphoramidite
(2-CYANOETHOXY)-2-(2''-O-1,1''-DIMETHOXYTRITYLOXYETHYLSULFONYL)- ETHOXY-N,N-DIISOPROPYLAMINOPHOSPHINE)
2-((2-(Bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)sulfonyl)ethyl (2-cyanoethyl) diisopropylphosphoramidite
Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-[[2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl]sulfonyl]ethyl 2-cyanoethyl ester | [Molecular Formula]
C34H45N2O7PS | [MDL Number]
MFCD00036168 | [MOL File]
108783-02-4.mol | [Molecular Weight]
656.77 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C, stored under nitrogen | [form ]
Liquid | [color ]
Colorless to light yellow | [Appearance]
colorless semisolid | [InChIKey]
RJDYWMSSNMDIOO-UHFFFAOYSA-N | [SMILES]
P(N(C(C)C)C(C)C)(OCCS(CCOC(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)(=O)=O)OCCC#N |
| Hazard Information | Back Directory | [Description]
Chemical phosphorylation reagent for the synthesis of 5’-phosphorylated oligonucleotides. The reagent contains a DMT group in its structure, which allows oligonucleotide purification on C18-cartridges or by reversed-phase chromatography. To yield 5’-phosphorylated oligonucleotide, remove DMT group and then deprotect the phosphate group with diluted ammonium solution (0.1 M). Deprotection of the phosphate group is rapid and efficient even under mild basic conditions, so this reagent can be used for DMT-Off synthesis, for example for RNA synthesis, or with dye phosphoramidites that require mild deprotection conditions.
Diluent: anhydrous acetonitrile. Add the diluent to the recommended concentration (0.1 M) and wait until reagent dissolution is complete while mixing periodically. This reagent is viscous amorphous, and it may take up to 10 minutes to dissolve it. Store the diluted reagent in anhydrous conditions for not more than 24 hours.
Coupling: 6 minutes | [Uses]
2-O-DMT-Sulfonyldiethanol phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides. | [Definition]
ChEBI: Beta-D-xylose is d-Xylopyranose in which the anomeric configuration is beta. |
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| Company Name: |
HitGen Inc. Gold
|
| Tel: |
028-85197385 13618381045 |
| Website: |
https://www.hitgen.com/ |
| Company Name: |
Cool Pharm, Ltd
|
| Tel: |
021-60455363 18019463053 |
| Website: |
www.coolpharm.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList1701258/0_EN.htm |
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