108784-42-5

33097-39-1

108784-42-5

The general procedure for the synthesis of 6-fluoropyridazin-3-amine from 3,6-difluoropyridazine was as follows: 3,6-difluoropyridazine (60.3 mmol) was mixed with 25 mL of ammonia in a sealed reaction tube and reacted at 70 °C for 2 hours. After completion of the reaction, it was cooled to room temperature and the precipitate was collected by filtration. Subsequently, the precipitate was washed with water and dried to give 6-fluoropyridazin-3-amine in a yield of 4.28 g. The reaction was carried out in a sealed reaction tube.