| Identification | Back Directory | [Name]
Rac1 Inhibitor II | [CAS]
1090893-12-1 | [Synonyms]
Rac1 Inhibitor II
Rac1 Inhibitor II - CAS 1090893-12-1 - Calbiochem
InSolution Rac1 Inhibitor II, Z62954982 - CAS 1090893-12-1 - Calbiochem
Benzamide, N-[3-(aminosulfonyl)-4-methylphenyl]-3-[(3,5-dimethyl-4-isoxazolyl)methoxy]- | [Molecular Formula]
C20H21N3O5S | [MDL Number]
MFCD11736677 | [MOL File]
1090893-12-1.mol | [Molecular Weight]
415.46 |
| Hazard Information | Back Directory | [General Description]
A cell-permeable isoxazolyl-benzamide compound that is more effective than NSC23766 (Cat. Nos. 553502 & 553508) in inhibiting PDGF-BB- (Cat. No. 521225) induced cellular Rac1 activation (45.8% vs 11.1% inhibition by 4 h pretreatment of the respective compound at 50 μM) in serum-starved SMCs (human aortic smooth muscle cells) by interfering Rac1-Tiam1 interaction, while exhibiting no effect toward cellular Cdc42 and RhoA activation or Rac1 interaction to its effector Pak1. Shown to effectively prevent PDGF-BB-induced membrane ruffling and lamellipodia formation in serum-starved 3T3 cells (4 h pretreatment at 25 μM). Also available in InSolution format (Cat. No. 553512). |
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Sigma-Aldrich
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Merck Millipore
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Merck KGaA
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MedChemExpress
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