| Identification | Back Directory | [Name]
2-[(3-chlorophenyl)amino]-N-(4-pyridinylmethyl)-4-(trifluoromethyl)-5-Pyrimidinecarboxamide hydrochloride | [CAS]
1092502-33-4 | [Synonyms]
GW833972A
GW 833972A hydrochloride
GW 833972A, 10 mM in DMSO
GW833972A >=98% (HPLC), powder
GW 833972A hydrochloride - Bio-X
2-[(3-Chlorophenyl)amino]-N-(4-pyridylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide Hydrochloride
2-[(3-chlorophenyl)amino]-N-(4-pyridinylmethyl)-4-(trifluoromethyl)-5-Pyrimidinecarboxamide hydrochloride | [Molecular Formula]
C18H14Cl2F3N5O | [MDL Number]
MFCD18452844 | [MOL File]
1092502-33-4.mol | [Molecular Weight]
444.238 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥20mg/mL | [form ]
powder | [color ]
off-white to light brown | [InChI]
1S/C18H13ClF3N5O.ClH/c19-12-2-1-3-13(8-12)26-17-25-10-14(15(27-17)18(20,21)22)16(28)24-9-11-4-6-23-7-5-11;/h1-8,10H,9H2,(H,24,28)(H,25,26,27);1H | [InChIKey]
UBHSVFAUAKIVKL-UHFFFAOYSA-N | [SMILES]
Cl.FC(F)(F)c1nc(Nc2cccc(Cl)c2)ncc1C(=O)NCc3ccncc3 |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25-36/37/38 | [Safety Statements ]
26-45 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Aquatic Chronic 4
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
GW833972A, a selective CB2 cannabinoid receptor agonist, may be used separately or in comparison to other cannabinoid receptor agonist and antagonists to differentiate and characterize the CB2 cannabinoid receptor. GW833972A may be used to help verify that an observed physiological response is cannabinoid receptor CB2-dependent. | [Biochem/physiol Actions]
The compound was used to determine the role of CB2 in airway sensory nerve function. | [in vivo]
GW 833972A (30 mg/kg, 2 mL/kg; i.p.; single dose 30 min before test) inhibits tussive response in conscious guinea pigs induced by citric acid. It also inhibits capsaicin-induced plasma protein exudation in the main bronchus[1]. | [IC 50]
hCB2-R: 7.3 (pEC50); rat CB2-R: 7.5 (pEC50) |
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