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1093119-54-0

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1093119-54-0 Structure

1093119-54-0 Structure
IdentificationBack Directory
[Name]

MKC3946
[CAS]

1093119-54-0
[Synonyms]

MKC3946
MKC3946;MKC-3946;MKC 3946
1-Naphthalenecarboxaldehyde, 2-hydroxy-6-[5-[(4-methyl-1-piperazinyl)carbonyl]-2-thienyl]-
[Molecular Formula]

C21H20N2O3S
[MOL File]

1093119-54-0.mol
[Molecular Weight]

380.46
Chemical PropertiesBack Directory
[storage temp. ]

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
[solubility ]

DMSO:20.0(Max Conc. mg/mL);52.57(Max Conc. mM)
[form ]

A crystalline solid
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Spectrum DetailBack Directory
[Spectrum Detail]

MKC3946(1093119-54-0)1HNMR
Hazard InformationBack Directory
[Biological Activity]

MKC3946 is a soluble inhibitor of the IRE1α endoribonuclease domain, causing moderate growth inhibition in multiple myeloma cell lines without toxic effects on normal monocytes.
[in vivo]

In an in vivo model of endoplasmic reticulum stress, MKC-3946 inhibits cleavage of XBP1 and significantly inhibits myeloma cell growth.
[target]

< /table>
TargetValue
IRE1α endoribonuclease
()
[storage]

Store at -20°C
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