| Identification | Back Directory | [Name]
MKC3946 | [CAS]
1093119-54-0 | [Synonyms]
MKC3946
MKC3946;MKC-3946;MKC 3946
1-Naphthalenecarboxaldehyde, 2-hydroxy-6-[5-[(4-methyl-1-piperazinyl)carbonyl]-2-thienyl]- | [Molecular Formula]
C21H20N2O3S | [MOL File]
1093119-54-0.mol | [Molecular Weight]
380.46 |
| Chemical Properties | Back Directory | [Boiling point ]
591.6±50.0 °C(Predicted) | [density ]
1.337±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMSO:20.0(Max Conc. mg/mL);52.57(Max Conc. mM) | [form ]
A crystalline solid | [pka]
8.18±0.50(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
MKC3946 is a potent IRE1α inhibitor, used for cancer research. | [Biological Activity]
MKC3946 is a soluble inhibitor of the IRE1α endoribonuclease domain, causing moderate growth inhibition in multiple myeloma cell lines without toxic effects on normal monocytes. | [in vivo]
In an in vivo model of endoplasmic reticulum stress, MKC-3946 inhibits cleavage of XBP1 and significantly inhibits myeloma cell growth. | [target]
| Target | Value | IRE1α endoribonuclease
() | < /table>[storage]
Store at -20°C | [References]
[1] Sun H, et al. Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia. Oncotarget. 2016 Apr 5;7(14):18736-49 DOI:10.18632/oncotarget.7702
[2] Zhang L, et al. IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosis. BMC Cell Biol. 2014 Jul 10;15:29. DOI:10.1186/1471-2121-15-29
[3] Mimura N, et al. Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma. Blood. 2012 Jun 14;119(24):5772-81 DOI:10.1182/blood-2011-07-366633 |
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Tags:1093119-54-0
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