| Identification | Back Directory | [Name]
PV-1115 | [CAS]
1093793-10-2 | [Synonyms]
PV-1115
1H-Indole-2-carboxamide, N-[4-[1-[2-(4,5-dihydro-1H-imidazol-2-yl)hydrazinylidene]ethyl]phenyl]-7-nitro- | [Molecular Formula]
C20H19N7O3 | [MOL File]
1093793-10-2.mol | [Molecular Weight]
405.41 |
| Hazard Information | Back Directory | [Uses]
PV1115 is a potent and highly selective Chk2 inhibitor with an IC50 of 0.14 nM, 66000 nM, >100000 nM for Chk2, Chk1 and RSK2, respectively. PV1115 is situated within the ATP-binding pocket of Chk2[1]. | [References]
[1] George T Lountos,
et al. Structural characterization of inhibitor complexes with
checkpoint kinase 2 (Chk2), a drug target for cancer therapy. J Struct Biol.
2011 Dec;176(3):292-301. DOI:10.1016/j.jsb.2011.09.008 |
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