| Identification | Back Directory | [Name]
1H-Pyrazole-4-propanamide, 1-(4-bromophenyl)-3-(4-chlorophenyl)-N-(methylsulfonyl)- | [CAS]
1097120-47-2 | [Synonyms]
HadAB-IN-1
1H-Pyrazole-4-propanamide, 1-(4-bromophenyl)-3-(4-chlorophenyl)-N-(methylsulfonyl)- | [Molecular Formula]
C19H17BrClN3O3S | [MOL File]
1097120-47-2.mol | [Molecular Weight]
482.78 |
| Hazard Information | Back Directory | [Uses]
HadAB-IN-1 is a potent HadAB inhibitor. HadAB-IN-1 inhibits HadAB enzyme complexes activity with an IC50 value of 0.03 μM. HadAB-IN-1 also affects mycolic acid biosynthesis in Mycobacterium tuberculosis (Mtb). HadAB-IN-1 can be used for the research of tuberculosis (TB)[1]. | [References]
[1] Vinayak Singh, et al. 1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis. ACS Infect Dis. 2022 Nov 11;8(11):2315-2326. DOI:10.1021/acsinfecdis.2c00392 |
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