| Identification | More | [Name]
PYRITHIOXIN | [CAS]
1098-97-1 | [Synonyms]
5-[[5-HYDROXY-4-(HYDROXYMETHYL)-6-METHYL-PYRIDIN-3-YL]METHYLDISULFANYLMETHYL]-4-(HYDROXYMETHYL)-2-METHYL-PYRIDIN-3-OL
PYRITHIOXIN
PYRITHIOXINE
PYRITINOL
3,3’-(dithiobis(methylene))bis(5-hydroxy-6-methyl-4-pyridinemethano
3,3’-(dithiobis(methylene))bis(5-hydroxy-6-methyl-4-pyridinemethanol)
3,3’-(dithiodimethylene)bis(5-hydroxy-6-methyl-4-pyridinemethano
biocefalin
bonol
dipyridoxolyldisulfide
encefabol
epocan
pyridoxine-5-disulfide
pyridoxinedisulfide
vitaminb6disulfide
bis(5-hydroxy-4-hydroxymethyl-6-methyl-3-pyridylmethyl) disulphide
pyrithioxin free base
Bis-[(3-Hydroxy-4-Hydroxymethyl-2-Methyl-5-Pyridyl)-Methyl]-Disulfide
PYRITINOL (PYRITHIOXINE) BASE
PYRITINOL (PYRITHIOXINE) HCL | [EINECS(EC#)]
214-150-1 | [Molecular Formula]
C16H20N2O4S2 | [MDL Number]
MFCD00151477 | [Molecular Weight]
368.47 | [MOL File]
1098-97-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
218-220° | [Boiling point ]
742.8±60.0 °C(Predicted) | [density ]
1.448±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Soluble in DMSO | [form ]
neat | [pka]
9.31±0.10(Predicted) | [color ]
White to Light yellow to Light orange | [Merck ]
14,7996 | [InChI]
InChI=1S/C16H20N2O4S2/c1-9-15(21)13(5-19)11(3-17-9)7-23-24-8-12-4-18-10(2)16(22)14(12)6-20/h3-4,19-22H,5-8H2,1-2H3 | [InChIKey]
SIXLXDIJGIWWFU-UHFFFAOYSA-N | [SMILES]
S(CC1=C(CO)C(O)=C(C)N=C1)SCC1=C(CO)C(O)=C(C)N=C1 | [CAS DataBase Reference]
1098-97-1(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
Pyritinol, the disulfide of pyridoxine-5-thiol,
is marketed as a cerebral stimulant in Europe.
Both the thiol and the disulfide have been shown
to have d-penicillamine-like activity in the treatment of rheumatoid arthritis. Adverse effects are
similar to those seen with d-penicillamine. Occasionally, pyritinol seems effective and better
tolerated in some individuals who fail to respond
to d-penicillamine. | [Uses]
cognition enhancer, nootropic | [Uses]
Pyritinol can be used as a nootropic used in the prevention and treatment of cerebrovascular diseases.
| [Definition]
ChEBI: Pyritinol is a member of methylpyridines. | [Brand name]
Biontabol;Bonifwn;Cefalogen;Cerebrotrofina;Cervitalin;Divalvon-d;Enbol;Encefort;Encerbrovit;Encerebron;Fulneurina;Geribolina;Gerontabol comp.;Juniormen;Leonar;Logos;Maind;Musa;Neuroxin;Piriditol;Piririomin;Piritinol;Piritiomin;Plenumil;Sawaxin;Scintidin;Tibased;Tomevit;Tonobrein;Tonomentis. | [World Health Organization (WHO)]
Pyritinol, which is claimed to promote the uptake of glucose in
the brain, is used in the treatment of cerebrovascular disorders. However, WHO is
not aware of controlled experimental data to show that it has any therapeutic effect. | [Synthesis]
Synthesis: treatment of pyridoxine with hydrobromic acid gives 4,5-bis(bromomethyl)-3-
hydroxy-2-methylpyridinium bromide, which
when treated in the cold with potassium
ethyl xanthate gives ethyl 4-hydroxymethyl-
3-hydroxy-2-methyl-3-pyridyl methylxanthate.
Hydrolysis and oxidation are carried out in
aqueous-alcoholic ammonia to give the disulfide
pyritinol.
 |
|
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Telephone: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
| Company Name: |
TCI Chemicals
|
| Telephone: |
021-67121386, 800-988-0390 |
| Website: |
www.tcichemicals.com |
|