| Chemical Properties | Back Directory | [Boiling point ]
349.8±37.0 °C(Predicted) | [density ]
1.031±0.06 g/cm3(Predicted) | [storage temp. ]
Store at Room Tem. | [Appearance]
colorless liquid |
| Hazard Information | Back Directory | [Uses]
m-PEG5-Propyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG5-Propyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [Biological Activity]
m-PEG5-Propyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs | [References]
[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1006. |
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| Company Name: |
Xinyanpomei
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| Tel: |
15850660754 |
| Website: |
http://www.xinyanpomei.com |
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