| Identification | Back Directory | [Name]
MPEG3-Propyne | [CAS]
89635-82-5 | [Synonyms]
mPEG3-Alkyne
MPEG3-Propyne
PROPARYL-PEG3-ME
m-PEG4-Propargyl
Proparyl-PEG4-methane
Propargyl-PEG3-methane
Propargyl-PEG4-methane
2,5,8,11-Tetraoxatetradec-13-yne
3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)prop-1-yne | [Molecular Formula]
C10H18O4 | [MDL Number]
MFCD27977518 | [MOL File]
89635-82-5.mol | [Molecular Weight]
202.25 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG4-methane is a crosslinking reagent that can react with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry to yield a stable triazole linkage. | [Uses]
Propargyl-PEG3-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-methane is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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