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1103522-80-0

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1103522-80-0 Structure

1103522-80-0 Structure
IdentificationBack Directory
[Name]

JNJ31001074AAC
[CAS]

1103522-80-0
[Synonyms]

JNJ31001074AAC
JNJ-31001074AAC
JNJ 31001074AAC
Bavisant (dihydrochloride hydrate)
JNJ-31001074AAC; JNJ 31001074AAC; JNJ31001074AAC
[Molecular Formula]

C19H30ClN3O3
[MDL Number]

MFCD26142924
[MOL File]

1103522-80-0.mol
[Molecular Weight]

383.92
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Water: ≥ 50 mg/mL (118.94 mM); DMSO: ≥ 1 mg/mL (2.38 mM)
[form ]

Powder
[color ]

White to pink
Hazard InformationBack Directory
[Uses]

Bavisant dihydrochloride hydrate (JNJ31001074AAC) is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H3 receptor. Bavisant dihydrochloride hydrate can be used for attention-deficit hyperactivity disorder (ADHD) research[1][2][3].
[in vivo]

Bavisant dihydrochloride hydrate increases acetylcholine levels in rat frontal cortex[4].

[IC 50]

H3 receptor
[References]

[1] Hudkins RL, et al. Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist. J Med Chem. 2011 Jul 14;54(13):4781-92. DOI:10.1021/jm200401v
[2] Weisler RH, et al. Randomized clinical study of a histamine H3 receptor antagonist for the treatment of adults with attention-deficit hyperactivity disorder. CNS Drugs. 2012 May 1;26(5):421-34. DOI:10.2165/11631990-000000000-00000
[3] Ghoshal A, et al. Identification of novel β-lactams and pyrrolidinone derivatives as selective Histamine-3 receptor (H3R) modulators as possible anti-obesity agents. Eur J Med Chem. 2018 May 25;152:148-159. DOI:10.1016/j.ejmech.2018.04.020
[4] Ghamari N, et al. Histamine H3 receptor antagonists/inverse agonists: Where do they go? Pharmacol Ther. 2019 Aug;200:69-84. DOI:10.1016/j.pharmthera.2019.04.007
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