| Identification | Back Directory | [Name]
JNJ31001074AAC | [CAS]
1103522-80-0 | [Synonyms]
JNJ31001074AAC
JNJ-31001074AAC
JNJ 31001074AAC
Bavisant (dihydrochloride hydrate)
JNJ-31001074AAC; JNJ 31001074AAC; JNJ31001074AAC | [Molecular Formula]
C19H30ClN3O3 | [MDL Number]
MFCD26142924 | [MOL File]
1103522-80-0.mol | [Molecular Weight]
383.92 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Water: ≥ 50 mg/mL (118.94 mM); DMSO: ≥ 1 mg/mL (2.38 mM) | [form ]
Powder | [color ]
White to pink |
| Hazard Information | Back Directory | [Uses]
Bavisant dihydrochloride hydrate (JNJ31001074AAC) is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H3 receptor. Bavisant dihydrochloride hydrate can be used for attention-deficit hyperactivity disorder (ADHD) research[1][2][3]. | [in vivo]
Bavisant dihydrochloride hydrate increases acetylcholine levels in rat frontal cortex[4]. | [IC 50]
H3 receptor | [References]
[1] Hudkins RL, et al. Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist. J Med Chem. 2011 Jul 14;54(13):4781-92. DOI:10.1021/jm200401v
[2] Weisler RH, et al. Randomized clinical study of a histamine H3 receptor antagonist for the treatment of adults with attention-deficit hyperactivity disorder. CNS Drugs. 2012 May 1;26(5):421-34. DOI:10.2165/11631990-000000000-00000
[3] Ghoshal A, et al. Identification of novel β-lactams and pyrrolidinone derivatives as selective Histamine-3 receptor (H3R) modulators as possible anti-obesity agents. Eur J Med Chem. 2018 May 25;152:148-159. DOI:10.1016/j.ejmech.2018.04.020
[4] Ghamari N, et al. Histamine H3 receptor antagonists/inverse agonists: Where do they go? Pharmacol Ther. 2019 Aug;200:69-84. DOI:10.1016/j.pharmthera.2019.04.007 |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
|