| Chemical Properties | Back Directory | [solubility ]
Ethanol : 2.4 mg/mL (5.44 mM; Need ultrasonic)| (insoluble) | [form ]
White powder | [color ]
White to off-white | [Water Solubility ]
Water : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) | [InChI]
1S/C21H36NO4P.2Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-21(23)22-20-16-14-19(15-17-20)18-27(24,25)26;;/h14-17H,2-13,18H2,1H3,(H,22,23)(H2,24,25,26);;/q;2*+1/p-2 | [InChIKey]
DGRFALMFDGBLCP-UHFFFAOYSA-L | [SMILES]
[Na+].[Na+].[P](=O)([O-])([O-])Cc1ccc(cc1)NC(=O)CCCCCCCCCCCCC |
| Hazard Information | Back Directory | [Uses]
S 32826 is a nanomolar inhibitor of autotaxin. | [in vivo]
Topical application of S32826 (2-10 mM; 2 h-5 d) disodium decreases intraocular pressure (IOP) in a dose- and time-dependent manner in rabbits[2].
S32826 (～2 μM; single intracameral injection) disodium reduces the IOP in rabbits, with the ocular hypotensive response lasting for more than 48 hrs[2].
S32826 (10 mg/kg; p.o., i.p., s.c., and i.v.) disodium shows poor in vivo stability and/or bioavailability[1]. | [IC 50]
Autotaxin: 8.8 nM (IC50) | [storage]
Store at -20°C, protect from light, stored under nitrogen |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|