| Identification | More | [Name]
RO 20-1724 | [CAS]
29925-17-5 | [Synonyms]
ro 20-172
RO 20-1724
Ro-20-1724 - CAS 29925-17-5 - Calbiochem
4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDONE
4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDINONE
4-(3-BUTOXY-4-METHOXY-BENZYL)IMIDAZOLIDIN-2-ONE
4-(3-BUTOXY-4-METHOXYPHENYL)METHYL-2-IMIDAZOLIDONE
4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one solid
4-[(3-BUTOXY-4-METHOXYPHENYL)METHYL]-2-IMIDAZOLIDINONE
4-[(3-Butoxy-4-methoxyphenyl)methyl]imidazolidin-2-one
2-Imidazolidinone, 4-[(3-butoxy-4-methoxyphenyl)methyl]- | [Molecular Formula]
C15H22N2O3 | [MDL Number]
MFCD00077397 | [Molecular Weight]
278.35 | [MOL File]
29925-17-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
125-127° | [Boiling point ]
483.8±25.0 °C(Predicted) | [density ]
1.099±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
ethanol: 7 mg/mL
| [form ]
solid
| [pka]
14.54±0.40(Predicted) | [color ]
White | [biological source]
synthetic (organic) | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months. | [CAS DataBase Reference]
29925-17-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
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| Hazard Information | Back Directory | [Description]
RO 20-1724 (29925-17-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 0.2 μM. Displays anti-inflammatory activity. Cell permeable | [Uses]
Ro 20-1724 is a cell-permeable, cAMP-specific phosphodiesterase type IV (PDE4) inhibitor (IC50 = 2 μM). It weakly inhibits PDE3 with a Ki value greater than 25 μM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. It is often used to study cAMP-related functions in vascular cells. | [Uses]
Ro 20-1724 Is an inhibitor of phosphodiesterase-4, and also very effective for patients with plaque psoriasis. Selective inhibitor of cAMP-specific phosphodiesterase. Selective PDE4 inhibitor. | [Definition]
ChEBI: 4-[(3-butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone is a member of methoxybenzenes. | [Biological Activity]
Widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC 50 = 2.0 μ M). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ . | [Biochem/physiol Actions]
Inhibitor of cAMP phosphodiesterase. IC50 33 μM in vascular smooth muscle of the aorta. | [storage]
Store at- 20°C | [References]
1) Soderling et al. (1998), Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase; Proc. Natl. Acad. Sci. USA, 95 8991
2) Nicholson et al. (1991), Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes; Trends Pharmacol. Sci., 12 19 |
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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