| Identification | More | [Name]
(S)-(+)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINE | [CAS]
110529-22-1 | [Synonyms]
(2S)-1-METHYL-ALPHA,ALPHA-DIPHENYL-2-PYRROLIDINEMETHANOL
ALPHA,ALPHA-DIPHENYL-N-METHYL-L-PROLINOL
(S)-(+)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINE
(S)-A,A-DIPHENYLMETHYLPROLINOL
(S)-A,A-DIPHENYL-N-METHYL-2-PYRROLIDINEMETHANOL
(S)-A,A-N-METHYL DIPHENYL-2-PYRROLIDINE METHANOL
(S)-ALPHA,ALPHA-DIPHENYLMETHYLPROLINOL
(S)-ALPHA,ALPHA-DIPHENYL-N-METHYL-2-PYRROLIDINEMETHANOL
(S)-(+)-DIPHENYL(1-METHYLPYRROLIDIN-2-YL)METHANOL
(S)-N-METHYL-ALPHA,ALPHA-DIPHENYL-2-PYRROLIDINE METHANOL
(S)-N-Methyl-alpha,alpha-diphenylpyrrolidinemethanol
Hydroxydiphenylmethylmethylpyrrolidine
a,a-Diphenyl-N-methyl-L-prolinol
(s)-n-methyl-à,à-diphenylpyrrolidinemethanol
(s)-α,α-diphenyl-n-methyl-2-pyrrolidinemethanol
à,à-diphenyl-n-methyl-l-prolinol
α,α-diphenyl-n-methyl-l-prolinol
1,1-Diphenyl-N-methyl-L-prolinol
ALPHA,ALPHA-DIPHENYL-N-METHYL-L-PROLINOL , EE 99%
ɑ,ɑ-Diphenyl-N-methyl-L-prolinol, 97%, ee 99+% | [EINECS(EC#)]
634-571-8 | [Molecular Formula]
C18H21NO | [MDL Number]
MFCD00145245 | [Molecular Weight]
267.37 | [MOL File]
110529-22-1.mol |
| Chemical Properties | Back Directory | [Appearance]
white to slightly yellow crystalline powder | [Melting point ]
66-72 °C | [alpha ]
+52° (c=1, CHCl3) | [Boiling point ]
406.8±25.0 °C(Predicted) | [density ]
1.116±0.06 g/cm3(Predicted) | [refractive index ]
55 ° (C=1, CHCl3) | [storage temp. ]
0-6°C | [solubility ]
sol hexane, benzene, toluene, Et2O, cyclohexane, dichloromethane | [form ]
Powder | [pka]
13.15±0.29(Predicted) | [color ]
white to pale-yellow | [Optical Rotation]
[α]20/D +55±3°, c = 1% in chloroform stab. with amylenes | [BRN ]
4749387 | [InChI]
1S/C18H21NO/c1-19-14-8-13-17(19)18(20,15-9-4-2-5-10-15)16-11-6-3-7-12-16/h2-7,9-12,17,20H,8,13-14H2,1H3/t17-/m0/s1 | [InChIKey]
XIJAGFLYYNXCAB-KRWDZBQOSA-N | [SMILES]
CN1CCC[C@H]1C(O)(c2ccccc2)c3ccccc3 | [CAS DataBase Reference]
110529-22-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [F ]
10-34 | [HS Code ]
29339900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
white to slightly yellow crystalline powder | [Uses]
(S)-(+)-2-[Hydroxy(diphenyl)methyl]-1-methylpyrrolidine is used for chiral ligand for the enantioselective addition of dialkylzincs, alkynylzinc, and cyanomethylzinc bromide to aldehydes; chiral ligand for the enantioselective Reformatsky reaction; chiral ligand for the enantioselective Diels-Alder reaction; chiral auxiliary for asymmetric polymerization.
| [Preparation]
Reaction of Phenylmagnesium Bromide with (S)-N-[(benzyloxy)carbonyl]proline methyl ester and subsequent reduction with Lithium Aluminum Hydride affords the (S)-(+)-2-[Hydroxy(diphenyl)methyl]-1-methylpyrrolidine in 83% overall yield.
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| Company Name: |
J & K SCIENTIFIC LTD. Gold
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|