ChemicalBook--->CAS DataBase List--->110690-43-2

110690-43-2

110690-43-2 Structure

110690-43-2 Structure
IdentificationBack Directory
[Name]

EMITEFUR
[CAS]

110690-43-2
[Synonyms]

BOF-A2
BOF-A-2
EMITEFUR
EMITEFUR USP/EP/BP
3-[[3-(Ethoxymethyl)-5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-1-yl]carbonyl]benzoic acid 6-(benzoyloxy)-3-cyano-2-pyridyl ester
3-[[3-(Ethoxymethyl)-5-fluoro-3,6-dihydro-2,6-dioxo-1(2H)-pyrim-idinyl]carbonyl]benzoic acid 6-(benzoyloxy)- 3-cyano-2-pyridinyl ester
Benzoic acid, 3-[[3-(ethoxymethyl)-5-fluoro-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]carbonyl]-, 6-(benzoyloxy)-3-cyano-2-pyridinyl ester
3-[[[3-(Ethoxymethyl)-5-fluoro-1,2,3,6-tetrahydro-2,6-dioxopyrimidin]-1-yl]carbonyl]benzoic acid 6-(benzoyloxy)-3-cyano-2-pyridinyl ester
[Molecular Formula]

C28H19FN4O8
[MDL Number]

MFCD00866471
[MOL File]

110690-43-2.mol
[Molecular Weight]

558.47
Chemical PropertiesBack Directory
[Melting point ]

162-164°
[Boiling point ]

755.1±70.0 °C(Predicted)
[density ]

1.52±0.1 g/cm3(Predicted)
[storage temp. ]

2-8°C
[pka]

-5.94±0.40(Predicted)
[CAS DataBase Reference]

110690-43-2
Hazard InformationBack Directory
[Uses]

Antineoplastic used in the treatment of stomach, colorectal, breast, nonsmall cell lung, and pancreatic cancers (inhibits DNA synthesis and RNA function).
[Hazard]

A poison by ingestion. A reproductive hazard.
[Chemical Properties]

Melting point 162~164℃. Acute toxicity LD50 in mice, male rats, female rats (mg/kg):>5000, 1850, 1934 Oral.
[Safety Profile]

A poison by ingestion andsubcutaneous routes. Experimental reproductive effects.Mutation data reported. When heated to decomposition itemits toxic vapors of NOx and F-.
Raw materials And Preparation ProductsBack Directory
[Raw materials]

N,N-Dimethylformamide-->1,4-Dioxane-->2,6-Dihydroxypyridine-->Isophthaloyl dichloride
Safety DataBack Directory
[Toxicity]

LD50 in mice, male rats, female rats (mg/kg): >5000, 1850, 1934 orally (Kiroshita)
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