| Identification | More | [Name]
2,6-Dimethoxypyridine | [CAS]
6231-18-1 | [Synonyms]
2,6-DIMETHOXYPYRIDINE
2,6-Dimethoxypyridine, 98+%
2,6-Dimethoxypyridine,99% | [EINECS(EC#)]
228-334-4 | [Molecular Formula]
C7H9NO2 | [MDL Number]
MFCD00006266 | [Molecular Weight]
139.15 | [MOL File]
6231-18-1.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless to light yellow liquid | [Boiling point ]
178-180 °C (lit.) | [density ]
1.053 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.503(lit.)
| [Fp ]
143 °F
| [storage temp. ]
Sealed in dry,Room Temperature | [form ]
clear liquid | [pka]
1.57±0.10(Predicted) | [color ]
Colorless to Almost colorless | [Specific Gravity]
1.053 | [BRN ]
1525332 | [InChI]
InChI=1S/C7H9NO2/c1-9-6-4-3-5-7(8-6)10-2/h3-5H,1-2H3 | [InChIKey]
IBTGEEMBZJBBSH-UHFFFAOYSA-N | [SMILES]
C1(OC)=NC(OC)=CC=C1 | [CAS DataBase Reference]
6231-18-1(CAS DataBase Reference) | [NIST Chemistry Reference]
Pyridine, 2,6-dimethoxy-(6231-18-1) |
| Questions And Answer | Back Directory | [Uses]
2,6-Dimethoxypyridine is widely used in drug molecules, such as enzyme inhibitors/agonists, anti-HIV drugs, antibacterial drugs, and anesthetics. |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S39:Wear eye/face protection .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S36:Wear suitable protective clothing . | [RIDADR ]
1993 | [WGK Germany ]
3
| [HazardClass ]
3.2 | [PackingGroup ]
III | [HS Code ]
29333990 | [Storage Class]
10 - Combustible liquids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless to light yellow liquid | [Synthesis]
(1) In a 500 mL three-necked flask, 29.6 g (0.2 mol) of 2,6-dichloropyridine, 16 g (0.4 mol) of sodium hydroxide solid, and 200 mL of methanol were added sequentially. A reflux condensing unit was installed, magnetic stirring was turned on and heated to reflux. After maintaining the reflux reaction for 8 hours, the heating was stopped. Most of the methanol solvent was evaporated by rotary evaporator under reduced pressure. After the reaction solution was cooled to room temperature, it was diluted with 100 mL of water. Extraction and separation were carried out with dichloromethane (100 mL×1), and the organic phases were combined and dried over anhydrous sodium sulfate. After filtration, the dichloromethane was removed by spin distillation under reduced pressure to obtain the crude 2,6-dimethoxypyridine. Finally, the target fractions were collected by purification via decompression distillation to obtain the colorless and transparent liquid product 2,6-dimethoxypyridine in 94% yield. | [References]
[1] Patent: CN106905229, 2017, A. Location in patent: Paragraph 0028; 0029 |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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