| Identification | Back Directory | [Name]
ENDURACIDIN HYDROCHLORIDE | [CAS]
11115-82-5 | [Synonyms]
enradin
ENRAMYCIN
ENRAMAYCIN
ENDURACIDIN
EnramycinHCl
EnraMycin PreMix
C107H138Cl2N26O31HCl
ENRAMYCIN HYDROCHLORIDE
ENDURACIDIN HYDROCHLORIDE
Enduracidin, 8%
(Contains 1% Rice Bran Oil, 1% Silica and 90% Corn Meal) | [EINECS(EC#)]
695-076-0 | [Molecular Formula]
C106H135Cl2N26O31R | [MDL Number]
MFCD00131018 | [MOL File]
11115-82-5.mol | [Molecular Weight]
2340.27 |
| Hazard Information | Back Directory | [Usage]
Enduracidin is a fermentation-derived cyclodepsipeptide antibiotic produced by Streptomyces fungicidicus. Enduracidin consists of two components: Enduracidin A and Enduracidin B. Enduracidin is used
as a feed additive for animals. | [Chemical Properties]
White or yellowish-white powder. Melting point: 226°C (turns brown), decomposes at 234-238°C. The crude product is generally used as a gray to gray-brown powder with a characteristic odor. Soluble in dilute hydrochloric acid. Oral LD50 in mice: 10 g/kg; in 4-week-old chickens: 523 mg/kg. | [Uses]
Enduracidin is a fermentation-derived cyclodepsipeptide antibiotic produced by Streptomyces fungicidicus. Enduracidin consists of two components: Enduracidin A and Enduracidin B. Enduracidin is used
as a feed additive for animals. | [Uses]
Enduracidin is a fermentation-derived cyclodepsipeptide antibiotic produced by Streptomyces fungicidicus. Enduracidin consists of two components: Enduracidin A and Enduracidin B. Enduracidin is used as a feed additive for animals. | [General Description]
Enramycin, formerly called enduracidin, was found in the culture broth of Streptomyces fungicidicus by Takeda Chemicals Industries in 1967. This antibiotic shows strong activity against gram-positive bacteria but not against gram-negative bacteria. It is not subject to any of the mechanisms of resistance against other antibiotics and shows activity against otherwise resistant strains. Enramycin was evaluated for human therapy, but it is now used as a feed additive for growth promotion in poultry. |
| Safety Data | Back Directory | [WGK Germany ]
2
| [RTECS ]
JZ4107000
| [Toxicity]
dog,LD50,intravenous,100mg/kg (100mg/kg),Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969. |
| Questions And Answer | Back Directory | [Description]
Enduracidin hydrochloride is also named Enramycin. It is a polypeptide antibiotic produced by Streptomyces fungicides. It has an antibacterial effect on Gram-positive bacteria and a growth promoting effect on chickens and pigs. Enramycin has been used as a preventive feed medication at the level of 3 to 10 ppm in poultry feed (chickens and pigs) since 1974. It can also be used to treat necrotic enteritis caused by C. perfringens.
| [Reference]
M. Ngoh, C. Wrzesinski, Y. Yang, E. Zschiesche, T. Madsen, C. Stephenson, L. Newman, L. Deetz, Evaluation of the Presence and Level of Enramycin in Broiler Tissues Following In-Feed Administration at Therapeutic Dose, The Journal of Applied Poultry Research, 2018, pfy031
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