ChemicalBook--->CAS DataBase List--->1119249-30-7

1119249-30-7

1119249-30-7 Structure

1119249-30-7 Structure
IdentificationBack Directory
[Name]

Propargyl-PEG3-Tos
[CAS]

1119249-30-7
[Synonyms]

Propargyl-PEG3-Tos
2-[2-(prop-2-yn-1-yloxy)ethoxy]ethyl 4-methylbenzene-1-sulfonate
Ethanol, 2-[2-(2-propyn-1-yloxy)ethoxy]-, 1-(4-methylbenzenesulfonate)
[Molecular Formula]

C14H18O5S
[MDL Number]

MFCD20134051
[MOL File]

1119249-30-7.mol
[Molecular Weight]

298.35
Chemical PropertiesBack Directory
[form ]

Oil
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Description]

Propargyl-PEG3-Tos is a PEG linker containing a tosyl group and a propargyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.
[Uses]

Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458)[1]. Tos-PEG2-O-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
[IC 50]

PEGs
[References]

[1] Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461. DOI:10.1021/acs.jmedchem.6b01781
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