| Identification | Back Directory | [Name]
Propargyl-PEG4-bromide | [CAS]
1308299-09-3 | [Synonyms]
1308299-09-3
Alkyne-PEG4-Br
PROPARGYL-PEG4-BR
Propargyl-PEG4-bromide
3,6,9,12-Tetraoxapentadec-14-yne, 1-bromo- | [Molecular Formula]
C11H19BrO4 | [MDL Number]
MFCD28950764 | [MOL File]
1308299-09-3.mol | [Molecular Weight]
295.17 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG4-bromide is a crosslinker that can be used in copper catalyzed azide-alkyne Click Chemistry to form a stable triazole linkage with azides. The bromide (Br) acts as a good leaving group for nucleophilic substitution reactions. | [Uses]
Propargyl-PEG4-Br is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Br is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG4-Br is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Non-cleavable Linker; PEGs | [References]
[1] Suzanne AKERS-RODRIGUEZ, et al. Compositions and methods for the treatment of bacterial infections. WO2019126353A2. |
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