| Identification | More | [Name]
2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-ethanol | [CAS]
111974-69-7 | [Synonyms]
QUETIAPINE-D4 FUMARATE
QUETIAPIN
2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-ethanol
Quetiapine
11-[4-[2-(2-Hydroxyethoxy)ethyl]piperazino]dibenzo[b,f][1,4]thiazepine
2-[2-[4-[Dibenzo[b,f][1,4]thiazepin-11-yl]piperazin-1-yl]ethoxy]ethanol | [EINECS(EC#)]
601-143-7 | [Molecular Formula]
C25H25D4N3O6S | [MDL Number]
MFCD08064204 | [Molecular Weight]
503.6 | [MOL File]
111974-69-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
172-173 °C | [Boiling point ]
556.5±60.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
H2O : < 0.1 mg/mL (insoluble) | [form ]
Powder | [pka]
14.41±0.10(Predicted) | [Stability:]
Very Hygroscopic | [LogP]
0.899 | [CAS DataBase Reference]
111974-69-7(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
antiviral | [Uses]
Labelled Quetiapine (Q510000). Used as an antipsychotic. | [Definition]
ChEBI: Quetiapine is a dibenzothiazepine, a N-alkylpiperazine and a N-arylpiperazine. It has a role as a serotonergic antagonist, a dopaminergic antagonist, a histamine antagonist, an adrenergic antagonist and a second generation antipsychotic. | [Brand name]
Seroquel (AstraZeneca). | [Biological Functions]
Quetiapine is a dibenzothiazepine with a brain receptor–binding profile similar to that of clozapine. Quetiapine binds
most effectively to histaminergic H1, adrenergic a1 and a2, and serotonergic 5-HT2A receptors in the brain and has
even lower affinity than clozapine for dopaminergic D2 receptors. Unlike clozapine, however, quetiapine also has
very low affinity for muscarinic receptors. | [General Description]
Quetiapine, 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-ethanol fumarate (2:1,salt) (Seroquel), is a white to off-white crystalline powderthat is moderately water soluble. Quetiapine is rapidly absorbed,and peak plasma levels occur 1 to 2 hours after administration.Food does not appreciably affect the absorptionof quetiapine. The compound is 83% bound to plasma proteinsand it has a mean elimination half-life of 7 hours.Administration of a single dose of 14C-quetiapine showedthat only 1% of the drug was excreted unchanged, with 73%excreted into the urine and approximately 30% excreted inthe feces.Numerous metabolites of quetiapine are known,and the sulfoxide metabolite represents the major metabolitepresent in plasma. This metabolite is pharmacologicallyinactive. The remaining metabolites represent only5% of the total radioactivity found in plasma. The 7-hydroxyand the 7-hydroxy-N-desalkyl are active metabolites, but because of their low concentrations in plasma are not thoughtto contribute to the overall effects of quetiapine.
Common side effects associated with quetiapine therapyare orthostatic hypotension and somnolence. These effects are presumably caused by -adrenergic and histamine H1 receptorblockade, respectively. As with other atypical antipsychotics,patients treated with quetiapine should be monitoredfor hyperglycemic symptoms. Also, children and adolescentswith major depressive disorder may experience an increase intheir depression or suicidal tendencies.typical antipsychotics such as chlorpromazine.This findingmay explain the lack of EPS associated with quetiapine. | [Clinical Use]
Schizophrenia
Mania in bipolar disorder
Depression in bipolar disorder | [Side effects]
Quetiapine is 100% bioavailable, but first-pass metabolism yields at least
20 metabolites via CYP3A4, with a half-life of approximately 6 hours. Quetiapine is about as effective as haloperidol
in treating the positive symptoms of schizophrenia, but it also manages negative symptoms and induces a lower
incidence of extrapyramidal side effects. | [Drug interactions]
Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: increased risk of convulsions with
tramadol; enhanced hypotensive and sedative
effects with opioids; increased risk of ventricular
arrhythmias with methadone.
Anti-arrhythmics: increased risk of ventricular
arrhythmias.
Antibacterials: concentration possibly increased by
macrolides - avoid.
Antidepressants: concentration of tricyclics possibly
increased.
Antiepileptics: antagonism of convulsive threshold;
metabolism accelerated by carbamazepine and
phenytoin; concentration possibly increased by
valproate.
Antifungals: concentration possibly increased by
imidazoles and triazoles - avoid.
Antimalarials: manufacturer advises avoid use with
artemether and lumefantrine.
Antipsychotics: possible increased risk of ventricular
arrhythmias with risperidone.
Antivirals: concentration possibly increased by
atazanavir, boceprevir, darunavir, fosamprenavir,
indinavir, lopinavir, ritonavir, saquinavir, telaprevir
and tipranavir - avoid.
Anxiolytics and hypnotics: enhanced sedative effects.
Atomoxetine: increased risk of ventricular
arrhythmias.
Cytotoxics: increased risk of ventricular arrhythmias
with arsenic trioxide.
Grapefruit juice: concentration of quetiapine possibly
increased - avoid. | [Metabolism]
Quetiapine is extensively metabolised in the liver by
sulfoxidation mediated mainly by the cytochrome P450
isoenzyme CYP3A4 and by oxidation. The primary
metabolite is norquetiapine, which is also eliminated by
CYP3A4. Following the administration of radiolabelled
quetiapine, the parent compound accounted for less than
5% of unchanged drug-related material in the urine or
faeces. Approximately 73% of the radioactivity is excreted
in the urine and 21% in the faeces, mainly as inactive
metabolites. |
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