| Identification | More | [Name]
1-Fluoro-3-iodobenzene | [CAS]
1121-86-4 | [Synonyms]
1-FLUORO-3-IODOBENZENE
3-FLUOROIODOBENZENE
M-FLUOROIODOBENZENE
1-fluoro-3-iodo-benzen
3-Iodofluorobenzene
m-Fluorobenzene
m-Iodofluorobenzene
3-Fluoroiodobenzene 99%
3-Fluoroiodobenzene99%
3-Fluoroiodobenzene (stabilized with Copper chip)
1-Fluoro-3-iodobenzene, 98+%
Benzene, 1-fluoro-3-iodo-
1-Iodo-3-fluorobenzene
3-Fluoro-1-iodobenzene | [EINECS(EC#)]
214-339-9 | [Molecular Formula]
C6H4FI | [MDL Number]
MFCD00001044 | [Molecular Weight]
222 | [MOL File]
1121-86-4.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [TSCA ]
T | [HazardClass ]
IRRITANT | [HS Code ]
29039990 |
| Hazard Information | Back Directory | [Chemical Properties]
clear yellow or pink liquid | [Uses]
3-Fluoroiodobenzene was used to prepare methyl 4-iodobenzo[b]thiophene-2-carboxylate, key intermediate for the synthesis of 4-substituted benzo[b]thiophene-2-carboxamidines. | [General Description]
3-Fluoroiodobenzene participates in palladium-catalyzed hydroarylation of arylpropiolamides. | [Synthesis]
The general procedure for the synthesis of m-fluoroiodobenzene from 3-fluoroaniline was as follows: an aqueous solution (20 mL) of NaNO2 (6.4 g, 92.75 mmol) was slowly added dropwise at 0 °C to a solution of 3-fluoroaniline (10 g, 90.09 mmol) dissolved in 32% H2SO4 (179 g). The reaction mixture was stirred continuously at 0 °C for 1 hour. Subsequently, an aqueous solution (30 mL) of KI (22.4 g, 134.94 mmol) was added while maintaining 0 °C and stirring was continued at 0 °C for 1 hour. After completion of the reaction, the aqueous phase was extracted with EtOAc (2 x 250 mL). The organic phases were combined and washed sequentially with water (5×200mL) and 10% NaHSO3 solution (3×200mL), dried over Na2SO4 and concentrated under reduced pressure to remove the solvent, yielding 17.7 g of 1-fluoro-3-iodobenzene as a yellow solid in 82% yield. | [References]
[1] Patent: WO2008/103615, 2008, A1. Location in patent: Page/Page column 40
[2] Journal of the American Chemical Society, 1963, vol. 85, p. 709 - 724 |
|
|