| Identification | More | [Name]
3-METHYL-1-PHENYLPYRAZOLE | [CAS]
1128-54-7 | [Synonyms]
3-METHYL-1-PHENYL-1H-PYRAZOLE
3-METHYL-1-PHENYLPYRAZOLE
3-METHYL-1-PHENYLPYRAZOLE 98%
3-Methyl-1-Phenyl-5-Pyrazolone,Gpr | [EINECS(EC#)]
214-438-7 | [Molecular Formula]
C10H10N2 | [MDL Number]
MFCD00003123 | [Molecular Weight]
158.2 | [MOL File]
1128-54-7.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystals | [Melting point ]
34-36 °C(lit.) | [Boiling point ]
255-256℃ (752 Torr) | [density ]
1,076 g/cm3 | [refractive index ]
1.5870 (589.3 nm 20℃) | [Fp ]
>230 °F
| [storage temp. ]
Sealed in dry,Room Temperature | [form ]
Crystals | [pka]
0.87±0.10(Predicted) | [color ]
White | [Water Solubility ]
Insoluble in water. | [BRN ]
117870 | [CAS DataBase Reference]
1128-54-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [HS Code ]
29331990 |
| Hazard Information | Back Directory | [Chemical Properties]
white crystals | [Uses]
3-Methyl-1-phenyl-1H-pyrazole is used to produce 3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde at the temperature of 90-100°C with reagent phosphorus oxychloride. | [Synthesis]
GENERAL METHOD: 3-methylpyrazole (1.47 mmol), CuI (Sigma-Aldrich, 99.999% purity, 0.147 mmol), MnF2 (Sigma-Aldrich, 98% purity, 0.441 mmol), KOH (2.94 mmol) and iodobenzene (2.21 mmol) were added sequentially to the reaction vial along with trans-1 , 1 , 2-diaminocyclohexane (0.294 mmol) and water (0.75 mL). 2-diaminocyclohexane (0.294 mmol) and water (0.75 mL) were sequentially added to the reaction vial and fitted with screw caps to seal. The reaction mixture was stirred at 60 °C for 24 h in air. Upon completion of the reaction, it was cooled to room temperature, the reaction mixture was diluted with dichloromethane and filtered through a diatomaceous earth pad. The organic phases were combined, dried with anhydrous Na2SO4 and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography to give 3-methyl-1-phenylpyrazole. The structure and purity of the product were confirmed by 1H NMR and 13C NMR spectral analysis. | [References]
[1] Chemical Communications, 2009, # 41, p. 6258 - 6260
[2] Advanced Synthesis and Catalysis, 2009, vol. 351, # 5, p. 720 - 724
[3] Tetrahedron Letters, 2011, vol. 52, # 52, p. 7171 - 7174
[4] Advanced Synthesis and Catalysis, 2010, vol. 352, # 17, p. 2892 - 2898 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Maya High Purity Chemicals
|
| Telephone: |
+86 (573) 82222445 (0)18006601000 452520369 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15221/0_EN.htm |
| Company Name: |
Cool Pharm, Ltd
|
| Telephone: |
021-60455363 18019463053 |
| Website: |
www.coolpharm.com |
|