| Identification | Back Directory | [Name]
L-Asparagine, L-a-aspartyl-L-seryl-L-histidyl-L-alanyl-L-lysyl-L-arginyl-L-histidyl-L-histidylglycyl-L-tyrosyl-L-lysyl-L-arginyl-L-lysyl-L-phenylalanyl-L-histidyl-L-a-glutamyl-L-lysyl-L-histidyl-L-histidyl-L-seryl-L-histidyl-L-arginylglycyl-L-tyrosyl-L-arginyl-L-seryl-L-asparaginyl-L-tyrosyl-L-leucyl-L-tyrosyl-L-a-aspartyl- | [CAS]
112844-49-2 | [Synonyms]
L-Asparagine, L-a-aspartyl-L-seryl-L-histidyl-L-alanyl-L-lysyl-L-arginyl-L-histidyl-L-histidylglycyl-L-tyrosyl-L-lysyl-L-arginyl-L-lysyl-L-phenylalanyl-L-histidyl-L-a-glutamyl-L-lysyl-L-histidyl-L-histidyl-L-seryl-L-histidyl-L-arginylglycyl-L-tyrosyl-L-arginyl-L-seryl-L-asparaginyl-L-tyrosyl-L-leucyl-L-tyrosyl-L-a-aspartyl- | [Molecular Formula]
C178H258N64O48 | [MOL File]
112844-49-2.mol | [Molecular Weight]
4062.35 |
| Chemical Properties | Back Directory | [form ]
Solid | [color ]
White to off-white | [Sequence]
Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr-Arg-Ser-Asn-Tyr-Leu-Tyr-Asp-Asn |
| Hazard Information | Back Directory | [Uses]
Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 μM[1]. | [References]
[1] A Basak, et al. Histidine-rich human salivary peptides are inhibitors of proprotein convertases furin and PC7 but act as substrates for PC1. J Pept Res. 1997 Jun;49(6):596-603. DOI:10.1111/j.1399-3011.1997.tb01168.x |
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