| Identification | Back Directory | [Name]
Robotnikinin | [CAS]
1132653-79-2 | [Synonyms]
Robotnikinin
N-(4-chlorobenzyl)-2-((2R,6S,E)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl)acetamide
1-Oxa-4-azacyclododec-8-ene-6-acetamide, N-[(4-chlorophenyl)methyl]-5,12-dioxo-2-phenyl-, (2R,6S,8E)-
N-[(4-chlorophenyl)methyl]-2-[(2R,6S,8E)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl]acetamide | [Molecular Formula]
C25H27ClN2O4 | [MDL Number]
MFCD28899414 | [MOL File]
1132653-79-2.mol | [Molecular Weight]
454.95 |
| Hazard Information | Back Directory | [Description]
Robotnikinin is an inhibitor of Shh signaling in a concentration-dependant manner. It acts by displaying significant repression of Shh-induced Gli1/Gli2. | [Uses]
Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo[1][2]. | [storage]
Store at -20°C | [References]
[1] Manuel Hitzenberger, et al. The Binding Mode of the Sonic Hedgehog Inhibitor Robotnikinin, a Combined Docking and QM/MM MD Study. Front Chem DOI:10.3389/fchem.2017.00076
[2] Benjamin Z Stanton, et al. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol. 2009 Mar;5(3):154-6. DOI:10.1038/nchembio.142
[3] Ronald S Petralia, et al. Sonic hedgehog promotes autophagy in hippocampal neurons. Biol Open. 2013 Apr 8;2(5):499-504. DOI:10.1242/bio.20134275
[4] Ke Cai, et al. Targeting the cross-talk between the hedgehog and NF-κB signaling pathways in multiple myeloma. Leuk Lymphoma. 2019 Mar;60(3):772-781. DOI:10.1080/10428194.2018.1493727 |
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Creative Enzymes
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1-516-855-7709 |
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www.creative-enzymes.com |
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