| Identification | More | [Name]
(R)-Bicalutamide | [CAS]
113299-40-4 | [Synonyms]
(R)-(-)-BICALUTAMIDE
(R)-BICALUTAMIDE
N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Flurophenyl)Thio]-2-Hydroxy-2-Methyl-Propanamide
R-BICALUTIMIDE
(R)-Casodex
Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-, (2R)-
Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-, (R)-
(2R)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
(2R)-N-[3-(Trifluoromethyl)-4-cyanophenyl]-2-methyl-2-hydroxy-3-(4-fluorophenylsulfonyl)propanamide
(R)-N-[3-(Trifluoromethyl)-4-cyanophenyl]-2-methyl-2-hydroxy-3-(4-fluorophenylsulfonyl)propanamide
(R)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
ICI-187555 | [EINECS(EC#)]
692-949-8 | [Molecular Formula]
C18H14F4N2O4S | [MDL Number]
MFCD00870866 | [Molecular Weight]
430.37 | [MOL File]
113299-40-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-White Crystalline Solid | [Melting point ]
178-181°C | [Boiling point ]
650.3±55.0 °C(Predicted) | [density ]
1.52±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Acetone (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
11.49±0.29(Predicted) | [color ]
White to Off-White | [Usage]
(R)-Enantiomer of Bicalutamide. Used as an antiandrogen, antineoplastic (hormonal) | [CAS DataBase Reference]
113299-40-4(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Crystalline Solid | [Uses]
(R)-Bicalutamide can be used as an antiandrogen, antineoplastic (hormonal).
| [Definition]
ChEBI: (R)-bicalutamide is a N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide that is the (R)-enantiomer of bicalutamide. It has a role as an androgen antagonist and an antineoplastic agent. It is an enantiomer of a (S)-bicalutamide. | [in vivo]
(R)-Bicalutamide (10 mg/kg; i.g.; daily; for 4 days) has antitumor efficacy in VCaP xenografts mice[3].
| Animal Model: | CD1 male nude (nu/nu) mice, with VCaP xenografts[3] | | Dosage: | 10 mg/kg | | Administration: | Orally gavage, daily, for 4 consecutive weeks | | Result: | Suppressed tumor growth. |
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