Log in | Join Free | china | japan | germany
ChemicalBook--->CAS DataBase List--->1135318-57-8

1135318-57-8

Request For Quotation
1135318-57-8 Structure

1135318-57-8 Structure
IdentificationBack Directory
[Name]

MLS-0315848 hydrochloride
[CAS]

1135318-57-8
[Synonyms]

MLS-0315848 hcl
ML095 hydrochloride
MLS-0315848 hydrochloride
CID-25067483 hydrochloride
1-(3,4-Dihydroxyphenyl)-2-(3-ethyl-1H-pyrazol-1-yl)ethanone Hydrochloride
1-(3,4-Dihydroxyphenyl)-2-(2-ethyl-1H-imidazol-1-yl)-Ethanone hydrochloride
[Molecular Formula]

C13H15ClN2O3
[MDL Number]

MFCD25563261
[MOL File]

1135318-57-8.mol
[Molecular Weight]

282.72
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

H2O: soluble5mg/mL, clear
[form ]

powder
[color ]

white to beige
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

22-37/38-41
[Safety Statements ]

26-39
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

1-(3,4-Dihydroxyphenyl)-2-(3-ethyl-1H-pyrazol-1-yl)ethanone Hydrochloride is a biochemical inhibitor of placental alkaline phosphatase (PLAP) and is used to elucidate the key biological functions and natural substrates of human PLAP.
[Biological Activity]

ml-095 (hydrochloride) is a specific plap inhibitor [1].alkaline phosphatases are hydrolase enzymes responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. there are three isozymes of alkaline phosphatases: placental alkaline phosphatase (plap), intestinal alkaline phosphatase (iap), and tissue non-specific alkaline phosphatase (tnap). placental alkaline phosphatase (plap) is highly expressed in primate placental tissue and the biological function is still unknown. however, plap-like enzymes are detected in serum of patients with primary testicular tumors, in particular seminoma and other cancers [1].ml-095 (cid-25067483) is a biochemical inhibitor of plap and will be useful to elucidate the key biological functions and natural substrates of human plap. ml095 is a specific plap inhibitor and inhibited plap, tnap and iap with ic50 values of 2.1, >100 and 53 μm, respectively. ml095 exhibited greater than 25-fold selectivity over tissue non-specific alkaline phosphatase (tnap) and intestinal alkaline phosphatase (iap) [1].
[storage]

Store at -20°C
[References]

[1]. lanier m, cashman j, sergienko e, et al. placental alkaline phosphatase (plap) luminescent hts assay - probe 2.
1135318-57-8 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 15093356674; , 15093356674;
Website: https://www.coreychem.com/
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105 , +1-13798911105
Website: https://www.invivochem.com/
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525 , +8618327326525
Website: topule.com/
Company Name: Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Tel: +86-18341751992 +86-15382112998 , +86-15382112998
Website:
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Website: www.aladdinsci.com/
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Tel: 021-52996696，15000506266 15000506266
Website: http://www.bioll.com
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 021-13816613772 13816613772
Website: https://www.chemicalbook.com/ShowSupplierProductsList16976/0.htm
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: Shanghai Rechem science Co., Ltd.  
Tel: 21-31433387 15618786686
Website: cn.rechemscience.com
Company Name: MQ (shanghai) Pharmaceuticals Co., Ltd.  
Tel: 13761635123
Website: http://www.linyuepharm.com/
Company Name: DC Chemicals  
Tel: 021-58447131 13564518121
Website: https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm
Company Name: Changzhou Chenhong Biotechnology Co., Ltd.  
Tel: 0519-85788828 13775037613
Website: http://www.chemrenblock.com/
Company Name: ShangHai ChuanQian Chemcial Technique Centre  
Tel: 15869524721
Website: https://www.chemicalbook.com/ShowSupplierProductsList68594/0.htm
Company Name: Energy Chemical  
Tel: 021-58432009 400-005-6266
Website: http://www.energy-chemical.com
Company Name: MedBioPharmaceutical Technology Inc  
Tel: 021-69568360 18916172912
Website: http://www.med-bio.cn/
Company Name: Wuhan Topule  
Tel: +86-02787215551 +86-19945035818
Website: http://www.topule.com/
Company Name: Wuhan Augda Biotechnology Co., Ltd  
Tel: 15071299552
Website: https://www.chemicalbook.com/supplier/24275232/1.htm
Tags:1135318-57-8 Related Product Information