| Identification | Back Directory | [Name]
1,2-Ethanediol, 1-[5-[[3-[(2-methyl-3-pyridinyl)oxy]-5-(2-pyridinylthio)-2-pyridinyl]amino]-1,2,4-thiadiazol-3-yl]-, (1S)- | [CAS]
1138669-65-4 | [Synonyms]
1,2-Ethanediol, 1-[5-[[3-[(2-methyl-3-pyridinyl)oxy]-5-(2-pyridinylthio)-2-pyridinyl]amino]-1,2,4-thiadiazol-3-yl]-, (1S)- | [Molecular Formula]
C20H18N6O3S2 | [MOL File]
1138669-65-4.mol | [Molecular Weight]
454.53 |
| Hazard Information | Back Directory | [Uses]
AMG-151 (ARRY-403) is a glucokinase agonist with fasting plasma glucose (FPG) lowering activity. AMG-151 showed a significant linear dose-response trend compared with placebo in a randomized, placebo-controlled Phase IIa study. The use of AMG-151 was associated with a higher incidence of hypoglycemia and hypertriglyceridemia. AMG-151 may serve as a potential compound for the inhibition of type 1 diabetes[1]. | [References]
[1] AMG 151 (ARRY-403), a novel glucokinase activator, decreases fasting and postprandial glycaemia in patients with type 2 diabetes |
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