| Identification | Back Directory | [Name]
1H-Imidazole-5-carboxaldehyde, 2-butyl-4-chloro-1-[(4-nitrophenyl)methyl]- | [CAS]
114773-20-5 | [Synonyms]
NIC
1H-Imidazole-5-carboxaldehyde, 2-butyl-4-chloro-1-[(4-nitrophenyl)methyl]- | [Molecular Formula]
C15H16ClN3O3 | [MOL File]
114773-20-5.mol | [Molecular Weight]
321.76 |
| Chemical Properties | Back Directory | [Melting point ]
87-88 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
508.1±40.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [pka]
1.29±0.60(Predicted) |
| Hazard Information | Back Directory | [Description]
NIC is an inhibitor of host invasion. It acts by targeting malaria merozoite surface protein-1 (MSP-1). It is also an inhibitor of VEGF binding to immobilized heparin. | [Uses]
NIC is a host invasion inhibitor. NIC can suppress host invasion by interacting with the major invasion-related protein, merozoite surface protein 1 (MSP-1). NIC prevents the invasion of Plasmodium falciparum and Plasmodium vivax into the host[1]. | [References]
[1] Chandramohanadas R, et al. Small molecule targeting malaria merozoite surface protein-1 (MSP-1) prevents host invasion of divergent plasmodial species. J Infect Dis. 2014 Nov 15;210(10):1616-26. DOI:10.1093/infdis/jiu296 |
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