| Identification | Back Directory | [Name]
2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE | [CAS]
115199-84-3 | [Synonyms]
ICI 199
ICI 199441
ICI199441HCl
441 hydrochloride
ICI 199,441 HYDROCHLORIDE
2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE | [Molecular Formula]
C21H25Cl3N2O | [MDL Number]
MFCD01074479 | [MOL File]
115199-84-3.mol | [Molecular Weight]
427.8 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at RT | [solubility ]
Soluble to 100 mM in DMSO and to 50 mM in ethanol | [form ]
White solid. | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Opioid agonists exert a broad range of effects on the immune system ranging from inflammatory response modulation to opioid and chemokine receptor expression. ICI 199441 is a selective κ-opioid agonist with analgesic properties. | [Biological Activity]
Highly potent κ agonist, 146-fold more active than U-50488 (trans-(?-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride ) in vitro . | [in vivo]
ICI 199441 (Wistar rats, 0.1 mg/kg, IV, once) administered 15 min before ischemia produces a potent antiarrhythmic effect[1]. | [IC 50]
κ Opioid Receptor/KOR | [storage]
Store at RT |
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Wuhan Topule
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