| Identification | Back Directory | [Name]
1,2-dicholesterylheMisuccinoyl-sn-glycero-3-phosphocholine | [CAS]
1155878-69-5 | [Synonyms]
DChemsPC
1,2-dicholesterylheMisuccinoyl-sn-glycero-3-phosphocholine
1,2-DICHOLESTERYLHEMISUCCINOYL-SN-GLYCERO-3-PHOSPHOCHOLINE;DCHEMSPC | [Molecular Formula]
C70H116NO12P | [MDL Number]
MFCD22416948 | [MOL File]
1155878-69-5.mol | [Molecular Weight]
1194.67 |
| Hazard Information | Back Directory | [Uses]
DChemsPC might be used:
- as a substitute for cholesterol in liposome formulation to study its effect on membrane stability
- in the preparation of pH-gradient liposomes
- to form sterol-phospholipid hybrid with palmitoyl-2-cholesterylhemisuccinoyl-sn-glycero-3-phosphocholine (PCholPC) and to study its properties and interactions
| [Biological Activity]
Liposome instability in blood is caused mainly due to cholesterol exchange. Sterol modified phospholipid retains the bilayer-stabilizing effect of free cholesterolinhibiting its transfer from the bilayer. Thereforedisterolphospholipids are ideal for liposome preparation. The use of DChemsPC in liposomes prevents content leaking into the serum. |
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