ChemicalBook--->CAS DataBase List--->116-43-8

116-43-8

116-43-8 Structure

116-43-8 Structure
IdentificationMore
[Name]

p-2-Thiazolylsulfamoylsuccinanilic acid
[CAS]

116-43-8
[Synonyms]

2-(n(4)-succinylsulfanilamido)thiazole
2-(N-SUCCINYLSULFANILAMIDO)THIAZOLE
4'-(2-THIAZOLYLSULFAMOYL)-SUCCINANILIC ACID
colistatin
cremosuxidine
kaoxidin
KAOXIDINE
p-2-thiazolylsulfamoylsuccinanilic acid
rolsul
SST
SUCCINYLSULFATHIAZOLE
SULFASUXIDINE
SULFENTERONE
THIACYL
4’-(2-thiazolylsulfamoyl)-succinanilicaci
4-oxo-4-((4-((2-thiazolylamino)sulfonyl)phenyl)amino)-butanoicaci
succinylsulphathiazole
sulfadigesin
sulfasuccidin
sulfasuccidine
[EINECS(EC#)]

204-141-0
[Molecular Formula]

C13H13N3O5S2
[MDL Number]

MFCD00022437
[Molecular Weight]

355.39
[MOL File]

116-43-8.mol
Chemical PropertiesBack Directory
[Melting point ]

193.5°C
[density ]

1.4807 (rough estimate)
[refractive index ]

1.6390 (estimate)
[storage temp. ]

Sealed in dry,Room Temperature
[solubility ]

1 M NaOH: soluble50mg/mL
[form ]

powder
[pka]

pKa 4.5 (Uncertain)
[color ]

white to off-white
[Water Solubility ]

0.49g/L(38 ºC)
[λmax]

282nm(H2O (pH 3.3 - 5))(lit.)
[Merck ]

8877
[BRN ]

349989
[CAS DataBase Reference]

116-43-8(CAS DataBase Reference)
[EPA Substance Registry System]

116-43-8(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

R42/43:May cause sensitization by inhalation and skin contact .
[Safety Statements ]

S22:Do not breathe dust .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
[RIDADR ]

3249
[WGK Germany ]

3
[RTECS ]

WM4767000
[HazardClass ]

6.1(b)
[PackingGroup ]

III
[HS Code ]

29350090
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

p-2-Thiazolylsulfamoylsuccinanilic acid(116-43-8).msds
Hazard InformationBack Directory
[Originator]

Sulfasuxidine,MSD,US,1942
[Uses]

Succinylsulfathiazole is a sulfonamide antibiotic that was shown to inhibit bacteria that are responsible for folate production. Succinylsulfathiazole was used in various folate deficiency studies to block the synthesis of folic acid.
[Uses]

Succinylsulfathiazole is a sulfonamide antibiotic that was shown to inhibit bacteria that are responsible for folate production. Succinylsulfathiazole was used in various folate deficiency studies to block the synthesis of folic acid.
[Uses]

Succinylsulfathiazole is antibacterial
[Definition]

ChEBI: N-succinylsulfathiazole is a member of 1,3-thiazoles. It is functionally related to a sulfathiazole.
[Manufacturing Process]

3.92 g of succinic anhydride was added to a boiling suspension of 10 g of 2- sulfanilamidothiazole in 100 cc of alcohol. The mixture was then refluxed for five minutes after the addition was complete at which time all of the solids were in solution. The solution was then cooled and diluted with an equal volume of water. The white solid precipitate which formed was filtered and recrystallized from dilute alcohol, yielding 2-N4-succinylsulfanilamidothiazole, melting at 184°C to 186°C.
[Therapeutic Function]

Antibacterial (intestinal)
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

Succinylsulfathiazole(116-43-8)MS
Succinylsulfathiazole(116-43-8)IR1
Succinylsulfathiazole(116-43-8)IR2
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

116-43-8(sigmaaldrich)
[TCI AMERICA]

Succinylsulfathiazole  Hydrate,>97.0%(LC)(T)(116-43-8)
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