| Identification | Back Directory | [Name]
IDOXIFENE | [CAS]
116057-75-1 | [Synonyms]
cb7432
IDOXIFENE
SB 223030
iodoxifene
(e)-pyrrolidin
IDOXIFENE USP/EP/BP
pyrrolidino-4-iodotamoxifen
(e)-1-(2-(4-(1-(4-iodophenyl)-2-phenyl-1-butenyl)phenoxy)ethyl)pyrrolidine
(E)-1-(2-(4-(1-(4-Iodophenyl)-2-phenylbut-1-en-1-yl)phenoxy)ethyl)pyrrolidine
(E)-1-[4-(2-(Pyrrolidin-1-yl)ethoxy)phenyl]-1-(4-iodophenyl)-2-phenyl-1-butene
1-[2-[4-[(1E)-1-(4-Iodophenyl)-2-phenyl-1-buten-1-yl]phenoxy]ethyl]pyrrolidine
Pyrrolidine, 1-[2-[4-[(1E)-1-(4-iodophenyl)-2-phenyl-1-buten-1-yl]phenoxy]ethyl]- | [Molecular Formula]
C28H30INO | [MDL Number]
MFCD00865557 | [MOL File]
116057-75-1.mol | [Molecular Weight]
523.45 |
| Chemical Properties | Back Directory | [Melting point ]
108-109° (McCague et al.) | [Boiling point ]
573.4±50.0 °C(Predicted) | [density ]
1.329 | [storage temp. ]
2-8°C | [form ]
Solid | [pka]
9.61±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SERM for treatment of urogenital atrophy weak estrogen and antiestrogen in uterus | [Definition]
ChEBI: Idoxifene is a stilbenoid. | [in vivo]
Animals receive daily intraperitoneal injections of Estradiol (0.5 mg/kg) and an oral gavage of Idoxifene (0.02, 0.1, and 0.5 mg/kg) for 3 days after Dimethylnitrosamine (DMN) treatment. The blood levels of LDH and Estradiol (E2) and histological grades (scores 0 to 5) of liver zone 3 necrosis are evaluated. Idoxifene at doses of over 0.1 mg/kg significantly reduces the hepatic levels of collagen and MDA in the DMN model in a dose-dependent manner. Although Idoxifene and E2 are administered by different routes, i.e., by oral ingestion and intraperitoneal injection, respectively, the antifibrotic effect of a dose of 0.5 mg/kg of Idoxifene is somewhat greater than that of the same dose of E2[2]. |
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| Company Name: |
LGM Pharma
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| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
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