| Identification | Back Directory | [Name]
PHENAMIL METHANESULFONATE | [CAS]
1161-94-0 | [Synonyms]
MHPIZTURFVSLTJ-UHFFFAOYSA-N | [Molecular Formula]
C13 H16 Cl N7 O4 S | [MDL Number]
MFCD00274070 | [MOL File]
1161-94-0.mol | [Molecular Weight]
401.8 |
| Chemical Properties | Back Directory | [Appearance]
off-white to yellow solid | [storage temp. ]
2-8°C | [solubility ]
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble2.5mg/mL | [form ]
solid | [color ]
yellow | [Water Solubility ]
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.5mg/mL
DMSO: ≥5mg/mL (with warming)
0.1 M HCl: insoluble
H2O: insoluble | [CAS DataBase Reference]
1161-94-0 |
| Hazard Information | Back Directory | [Chemical Properties]
off-white to yellow solid | [Uses]
Phenamil Methanesulfonate Salt induced differentiation and peroxisome proliferator-activator receptor γ expression through ETS variant 4 in mouse preadipocyte | [General Description]
Phenamil, a derivative of amiloride is an inhibitor of sodium channels including acid sensing ion channel (ASIC) and epithelial sodium channels (ENaC). | [Biochem/physiol Actions]
Phenamil is an inducer of peroxisome proliferator-activated receptor γ (PPARγ) and inhibits diamine oxidase. By favoring tribbles homolog 3 (Trb3) expression, phenamil holds therapeutic potential to treat pulmonary artery hypertension (PAH) and idiopathic PAH. It is also a bone morphogenetic protein (BMP) activator, which favors osteogenesis and odontogenesis of stem cells. | [storage]
Store at -20°C |
|
| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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