| Identification | Back Directory | [Name]
TYRPHOSTIN AG 1288 | [CAS]
116313-73-6 | [Synonyms]
AG 1288
TYRPHOSTIN AG 1288
TYRPHOSTIN AG 1288 USP/EP/BP
(3,4-DIHYDROXY-5-NITROBENZYLIDENE) MALONONITRILE
ALPHA-CYANO-(3,4-DIHYDROXY-5-NITRO)CINNAMONITRILE
2-[(3,4-dihydroxy-5-nitrophenyl)methylidene]propanedinitrile
Propanedinitrile, 2-[(3,4-dihydroxy-5-nitrophenyl)methylene]- | [Molecular Formula]
C10H5N3O4 | [MDL Number]
MFCD00236451 | [MOL File]
116313-73-6.mol | [Molecular Weight]
231.16 |
| Hazard Information | Back Directory | [Uses]
Tyrphostin AG 1288 is a potent Tyrosine Kinase inhibitor. Tyrphostin AG 1288 inhibits ICAM1 expression and TNFα-mediated cytotoxicity in vitro[1]. | [Definition]
ChEBI: 2-[(3,4-dihydroxy-5-nitrophenyl)methylidene]propanedinitrile is a nitrophenol. | [References]
[1] Burke-Gaffney A, et al. Tumour necrosis factor-alpha-induced ICAM-1 expression in human vascular endothelial and lung epithelial cells: modulation by tyrosine kinase inhibitors. Br J Pharmacol. 1996 Nov;119(6):1149-58. DOI:10.1111/j.1476-5381.1996.tb16017.x |
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